胞必佳联合卡铂灌注治疗肺癌性胸腔积液的疗效观察  

Clinical effect of intrapleural cavity perfusion of Nocardia rubra cell wall skeleton combined with carboplatin treating pleural effusion arising from lung cancer

作　　者：胡贤主[1] 米建新[2] 

机构地区：[1]武警湖北总队医院一内科,武汉430061 [2]第四军医大学附属西京医院呼吸科

出　　处：《武警医学》2002年第5期262-264,共3页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的　观察胸腔闭式引流术后应用胞必佳 (Nocardiarubracellwallskeleten ,N -CWS)联合卡铂 (Carboplatin ,CBP)胸腔内灌注给药对肺癌性胸腔积液的疗效 ,并与引流术后应用卡铂腔内灌注给药的疗效进行比较。方法　 80例肺癌性胸腔积液患者随机分为胞必佳联合卡铂治疗组和卡铂治疗组 ,每组 4 0例 ,并观察两组疗效及副作用。结果　胞必佳联合卡铂组有效率达 95 % ,卡铂组有效率为 75 % ,两者比较 ,P <0 .0 5。结论　胸腔闭式引流后术胞必佳联合卡铂胸腔内灌注给药治疗肺癌性胸腔积液的疗效优于卡铂灌注给药。Objective To observe the effect of intrapleural cavity perfusion of Nocardia rubra cell wall skeleton (N-CWS) combined with carboplatin (CBP) after closed thoracic drainage.Methods Eighty patients were assigned to two groups randomly and compared with each other.One group (N CWS group,n=40) was treated with CBP,while the other (CBP group,n=40) was treated with CBP alone.Results The effective rates of the N CWS group and the CBP group were 95% and 75%,respectively (P<0.05).Conclusions The intrapleural cavity perfusion of N-CWS combined with CBP in treating pleural effusion arising from lung cancer is significantly more effective than that with CBP alone.

关 键 词：肺癌 胸腔积液 胞必佳 卡铂 胸腔闭式引流 治疗 

分 类 号：R734.205[医药卫生—肿瘤]