基质金属蛋白酶-2和基质金属蛋白酶-9在前列腺癌组织中表达的免疫组织化学研究  

Immunohistochemical studies of the expression of matrix metall oproteinase-2 and metalloproteinase-9 in human prostate cancer

作　　者：曾汉青[1] 肖亚军[1] 陈勇[2] 

机构地区：[1]华中科技大学同济医学院附属协和医院泌尿外科,武汉430022 [2]武汉大学中南医院泌尿外科

出　　处：《临床泌尿外科杂志》2002年第5期235-236,共2页Journal of Clinical Urology

摘　　要：目的 :探讨基质金属蛋白酶 2 (MMP 2 )和基质金属蛋白酶 9(MMP 9)在前列腺癌组织中的表达及其与前列腺癌侵袭的关系。方法 :采用免疫组织化学方法检测前列腺癌组织及良性前列腺增生组织中MMP 2和MMP 9的表达。结果 :前列腺癌组织中MMP 2和MMP 9的表达显著高于良性前列腺增生组织 (P <0 .0 1)。前列腺癌组织中MMP 2、MMP 9的表达与侵袭程度呈正相关。结论 :MMP 2和MMP 9是检测前列腺癌较好的分子标志 ,可用于前列腺癌的辅助诊断和预后判断。Purpose:To study the express of matrix metalloproteinase-2 and -9 in human prostate cancer.Methods:Matrix metalloproteinase-2 and -9 were detected by immunohistochemistry method in tissues of prostate cancer and BPH. Results:The matrix metalloproteinase-2 and -9 levels in prostate cancer were much higer than those in BPH, and the degree of cancer invasion positively correlated with the expression of the metalloproteinases. Conclusions:Matrix metalloproteinase-2 and -9 are pretty good molecular markers of prostate cancer which can be used to assist diagnosis and predict prognosis.

关 键 词：前列腺肿瘤 基质金属蛋白酶-2 基质金属蛋白酶-9 免疫组织化学 前列腺癌 

分 类 号：R737.25[医药卫生—肿瘤]