泛酸钙对全饥饿大鼠血清酮体、游离脂肪酸的影响  

THE EFFECT OF CALCIUM PANTOTHENATE ON SERUM KETONE BODY AND FREE FATTY ACID CONTENT IN STARVED RATS

作　　者：丁玉琴[1] 郭俊生[1] 赵法[1] 沈志雷[1] 秦海宏[1] 李敏[1] 

机构地区：[1]第二军医大学军队卫生教研室,上海200433

出　　处：《解放军预防医学杂志》2002年第2期90-92,共3页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：目的 :探讨泛酸钙对全饥饿大鼠可利用能源物质酮体 (KB)和游离脂肪酸 (FFA)的影响及可能的保护作用 ,为研制延长饥饿耐受时间的营养剂提供科学依据。方法 :以饥饿SD大鼠为模型 ,灌胃补充泛酸钙 ,观察饥饿后不同时期血清酮体和游离脂肪酸的变化。结果 :血清KB和FFA水平在饥饿后逐渐升高 ,分别于禁食 4d和 2d达到峰值 (2 .6 7± 0 .30 )mg·10 0ml- 1和(793.75± 99.85 ) μmol·L- 1,之后开始下降。泛酸钙补充后FFA峰值显著降低 (6 5 5 .92± 135 .12 )μmol·L- 1,禁食 9d的KB(0 .4 8± 0 .0 8)mg·10 0ml- 1和FFA(2 90 .4 6± 96 .4 9) μmol·L- 1水平显著高于全饥饿对照组的 (0 .4 0± 0 .0 7)mg·10 0ml- 1和 (16 7.4 3± 4 6 .78) μmol·L- 1,(P <0 .0 5 ,P <0 .0 1)。结论 :泛酸钙能延缓饥饿动物能源物质的消耗 。Objective:To study the effect of calcium pantothenate on serum ketone body (KB) and free fatty acid (FFA) content in starved rats,so as to provide scientific basis for preparing nutritional substance to prolong starvation tolerant time.Methods:Starved rats were supplemented with calcium pantothenate (125 mg·kg -1·d -1). Serum KB and FFA contents at different fasting times were examined.Results:Serum KB and FFA increased gradually following food deprivation in control rats and reached the peak value 〔(2.67±0.30) mg·100 ml -1,(793.75±99.85) μmol·L -1respectively〕on the 4th and 2 nd day respectively, then began to go down. The peak level of FFA in the supplemented rats was (655.92±135.12)μmol·L -1, lower than that in the control rats (P<0.05).On day 9 of fasting, KB and FFA contents 〔(0.48±0.08) mg·100 ml -1,〔(290.46±96.49)μmol·L -1 respectively〕in the supplemented rats were higher than those in fasting control 〔(0.40±0.07)mg·100 ml -1 and (167.43±46.78) μmol·L -1respectively〕,(P<0.05,P<0.01).Conclusion:Calcium pantothenate could slow down the process of energy consumption and may have certain protective role in starved rats.

关 键 词：饥饿 泛酸钙 酮体 游离脂肪酸 血清 

分 类 号：R151.4[医药卫生—营养与食品卫生学]