红葡萄酒及白藜三醇对血小板聚集的影响  

Effects of Red Wine and Resveratrol on Platelet Aggregation

作　　者：王志荣[1] 黄元铸[1] 邹建刚[1] 曹克将[1] 徐以南[1] 蔡海江[2] Joseph M.Wu 

机构地区：[1]南京医科大学附属第一医院心脏科,江苏省南京市210029 [2]南京医科大学动脉粥样硬化研究中心,江苏省南京市210029 [3]Department of Biochemistry and MolecularBiology NewYork Medical College

出　　处：《中国动脉硬化杂志》2002年第2期129-131,共3页Chinese Journal of Arteriosclerosis

摘　　要：观察红葡萄酒及其提取物白藜三醇对离体和在体条件下血小板聚集的影响 ,以探讨它们对心血管系统的保护作用机制。以高胆固醇饮食造成实验性高脂血症 ,以凝血酶、二磷酸腺苷和胶原为诱导剂 ,采用Born氏法测定血小板聚集率。结果发现 ,高脂饮食明显增加兔血浆胆固醇水平 ,并伴有血小板聚集的明显增强。同时给予红葡萄酒、去酒精红葡萄酒和白藜三醇可以消除高脂饮食对兔血小板聚集的增强作用。离体条件下白藜三醇明显抑制凝血酶、二磷酸腺苷及胶原诱导的健康人的血小板聚集。结果提示 ,红葡萄酒及白藜三醇均具有抑制血小板聚集的作用 ,此作用可能为白藜三醇抗动脉粥样硬化的机制之一。Aim To explore the cardioprotection mechanism of red wine and resveratrol, the effects of red wine and resveratrol on platelet aggregation both in vitro and in vivo were studied. Methods Hypercholesterolemia in rabbits was induced by high cholesterol diet. Platelet aggregation induced by thrombin, ADP and collagen was measured by using Born's method. Results Hypercholesterolemia induced by high cholesterol diet enhanced the platelet aggregation in rabbits. Red wine, de alcohol red wine or resveratrol were administered orally, which significantly inhibited ADP induced platelet aggregation in rabbits with hypercholesterolemia. In vitro resveratrol significantly inhibited healthy volunteers' platelet aggregation induced by thrombin, ADP or collagen in a concentration dependent manner. Conclusions Red wine and resveratrol can inhibit platelet aggregation both in vitro and in vivo. This may be one of the mechanisms by which resveratrol prevents against atherosclerosis.

关 键 词：红葡萄酒 白藜三醇 血小板聚集 高脂血症 

分 类 号：R972.6[医药卫生—药品]