磷脂水解与胆固醇型胆结石的可能生成机理  

Hydrolysis of Phospholipid and Possible Mechanism of Gallstone Formation

作　　者：徐怡庄[1,2] Somjen G. 杨展澜[1] 翁诗甫[1] 刘虎威[1] 李维红[1] 张煦[1] 吴瑾光[1] 徐端夫[2] 

机构地区：[1]北京大学化学系,稀土材料化学及应用国家重点实验室 [2]中国科学院化学研究所,高分子化学和物理国家重点实验室,北京100080

出　　处：《化学学报》2002年第4期711-714,共4页Acta Chimica Sinica

基　　金：国家重点基础研究发展规划项目 (No .G19980 6 130 7);国家自然科学基金 (Nos .2 990 10 0 2 ;2 96 710 0 2 ;39730 16 0 ;2 0 0 2 30 0 5 ;5 97330 6 0;5 98730 30 ;5 995 30 0 1;5 990 30 0 8);中国科学院知识创新工程 (No .KJCX1 Y 0 3);稀土材料化学国家重点实

摘　　要：用胆酸盐 -磷脂 -胆固醇 -水体系模拟胆汁的化学行为 .在体系中发现 ,磷脂可以发生降解形成脂肪酸 .而在胆汁中 ,磷脂在增溶胆固醇的过程中起到了十分重要的作用 .依此 ,我们提出磷脂的水解可能与胆固醇型胆结石的生成有密切关系 .Taurocholic salt-phospholipid-cholesterol-water solubilized systems were used to investigate the physical/chemical behavior of bile. Phase separation that produces float and precipitation was observed in the system. Analysis using FT-IR spectroscopy and GC-MS methods showed that aliphatic acids were principal component of the float. This demonstrated that hydrolysis of phospholipid must have occurred in the system. Considering that phospholipid plays a very important role in solubilizing cholesterol in bile, whereas aliphatic acids can not solubilize cholesterol, we suggest that the hydrolysis of phospholipid may be related to the formation of gallstone.

关 键 词：磷脂 水解 胆因醇型胆结石 生成机理 红外光谱 病理 胆石症 

分 类 号：R575.62[医药卫生—消化系统]