E—cadherin在肝细胞癌中的表达及其临床意义  

EXPRESSION OF E-CADHERIN MOLECULES IN HEPATOCELLUR CARCINOMA AND ITS CLINICAL IMPLICATION

作　　者：丁印鲁[1] 赵荣宇[2] 等 

机构地区：[1]山东大学齐鲁医院，山东济南250012 [2]大连医科大学第一附属医院，辽宁大连116011

出　　处：《医师进修杂志》2002年第5期26-28,共3页Journal of Postgraduates of Medicine

摘　　要：目的 研究上皮钙粘附素（E-cadherin)在肝细胞癌（hepatocellular carcinoma,HCC)中的表达情况。并探讨其临床意义。方法 采用免疫组织化学方法检测49例HCC病人手术后的存档石蜡切片组织中E-cadherin的表达情况，分别与肿瘤大小，癌灶数目，病理分级，甲胎蛋白，肝硬化，包膜，门脉瘤栓，乙肝表面抗原等临床病理指标对比。并分析其表达与术后无瘤生存时间的关系。结果 57.14%（28/49）的HCC病例E-cadherin的表达减弱，42.86%(21/49)的病例E-cadherin的表达正常，E-cadherin的表达与肿瘤大小，病理分级有相关性（P<0.05)。而与癌灶数目，甲胎蛋白，有无肝硬化，包膜情况，癌栓，乙肝表面抗原等无关（P>0.05)，E-cadherin正常表达组术后无瘤生存时间（月）显著高于表达减弱组（20.38±2.97vs10.43±2.23, P<0.05)。结论 E-cadherin减弱表达可能对HCC浸润转移起促进作用；E-cadherin的表达与HCC预后有关，可能是反映HCC生物学行为及预后的重要标志物。Objective\ To investigate the expression of E-cadherin protein in HCC and its clinical significance.Methods\ Expression of E-cadherin protein was detected immunohistochemically in paraffinmbedded specimens of 49 HCCs.Results were compared with clinicopathologic parameters.The relationship between E-cadherin expression and postoperative disease-free survival was explored.Results\ 28(57.14%)of 49 HCCs showed reduced E-cadherin expression,21( 42.86% ) normal E-cadherin expression.Significant correlation was found between E-cadherin expression and tumor size,Endmodson't grade (P<0.05).Postoperative disease-free survival in the HCCs group with normal E-cadherin expression was significantly longer than that of reduced E-cadherin expression ( 20.38 ±2.97 vs 10.43±2.23 months,P<0.05).Conclusion\ Reduced E-cadherin expression may potentially promote the metastasis in patients with HCC;E-cadherin is an important marker reflecting biological behavivors and prognosis of HCC.

关 键 词：临床意义 E-CADHERIN 肝细胞癌 免疫组织化学 上皮钙粘附素 肿瘤浸润 肿瘤转移 

分 类 号：R735.7[医药卫生—肿瘤]