左旋门冬酰胺酶治疗儿童急性淋巴细胞性白血病的胰腺毒副作用观察  

THE TOXICITY OF L-ASPARAGINASE TO PANCREAS IN TREATING CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

作　　者：屠立明[1] 李永康[1] 沈亦逵[1] 王春萍[1] 

机构地区：[1]广东省人民医院,广东广州510080

出　　处：《白血病．淋巴瘤》2002年第2期87-89,共3页Journal of Leukemia & Lymphoma

摘　　要：目的 :观察用左旋门冬酰胺酶 (L- ASP)治疗儿童急性淋巴细胞性白血病时引起的胰腺毒副作用及转归。方法 :用 VDL P方案治疗 12 8例 ,定期做血尿淀粉酶及血尿糖 (尿酮 )检测。结果 :8例 (6 .0 3% )出现胰腺毒副作用 ,年龄 9岁～ 13岁 ,均发生在诱导缓解治疗期 ,急性胰腺炎 5例 ,继发糖尿病 7例 (3例伴酮症酸中毒 ) ;4例上述两者并存。结论 :L- ASP引起的胰腺毒副作用与患儿年龄及个体敏感差异有关 ,与药物累积剂量及性别无关。急性胰腺炎和继发糖尿病可分别发生 。Objective:To observe the toxicity of pancreas from L asparaginase in treating childhood ALL and their recovery.Methods:128 cases ALL were treated with VDLP protocol.Their amylase and glucose in blood and urine were inspected regularly.Results:8 cases got toxicity on pancrease (6.03 %) and aged between 9 and 13,these occur during the remission induction therapy,5 cases got acute pancreatitis and 7 had hyperglycemia (3 with ketonic acidosis);4 cases got the both.Conclusion:The damage of the pancreas caused by L ASP may be related to the patients'age (elder children) and the individual reaction differentia and not to the sex and the accumulated doses of L ASP.Pancreatitis or hyperglycemia could occur respectively or simultaneously.

关 键 词：急性淋巴细胞性白血病 左旋门冬酰胺酶 急性胰腺炎 糖尿病 治疗 儿童 

分 类 号：R733.7[医药卫生—肿瘤]