盐酸维拉帕米脉冲释放片体内外释药特性  

Study on the in vitro and in vivo drug release of verapamil hydrochroride pulsatile release tablet

作　　者：范辉[1] 周晗瑛[1] 梁文权[2] 

机构地区：[1]浙江医科大学附属邵逸夫医院,浙江杭州310016 [2]浙江大学药学院,浙江杭州310006

出　　处：《中国医院药学杂志》2002年第5期271-274,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的 :研究盐酸维拉帕米脉冲释放片体内外释药特性。方法 :用干法压制包衣技术制备盐酸维拉帕米脉冲释放片 ,调整包衣中致孔剂用量 ,通过体外释放度试验考查时滞 ,并用HPLC法测定家兔血药浓度 ,考查体内外时滞的相关性。结果 :体内外时滞基本相符。结论OBJECTIVE To study the in vitro and in vivo drug release of verapamil hydrochloride pulsatile release tablet.METHODS Verapamil hydrochroride pulsatile release tablet was prepared using convenient dry coating techniques. A high performance liquid chromatography method was used to determine the plasma concentration of rabbits. The in vitro in vivo correlation was evaluated.RESULTS There was a good correlation between in vitro and in vivo lag time.CONCLUSIONS The in vivo lag time can be well predicated by in vitro value.

关 键 词：盐酸维拉帕米脉冲释放片 体内外释药特性 干压包衣片 时滞 心血管系统药 

分 类 号：R872[医药卫生—运动医学] R965.1[医药卫生—临床医学]