帕金森病猴模型脑多巴胺转运体SPECT显像  

The Dopamine Transporter SPECT Imaging in Hemiparkinsonian Monkeys' Brain

作　　者：陈玲[1] 胡平[2] 吴克宁[2] 黎锦如[1] 刘焯霖[1] 李春亿[2] 李伟明[2] 潘勇辉[1] 

机构地区：[1]中山大学附属第一医院神经科,广东广州510080 [2]中山大学附属第一医院核医学科,广东广州510080

出　　处：《中山医科大学学报》2002年第3期183-186,F003,共5页Academic Journal of Sun Yat-sen University of Medical Sciences

基　　金：国家自然科学基金资助课题 (3 9670 2 2 9)

摘　　要：【目的】探讨脑多巴胺转运体SPECT显像在帕金森病诊断中的应用价值及吡贝地尔治疗对脑多巴胺转运体的影响。【方法】正常恒河猴经右侧颈总动脉注射 (一次或多次 ) 1 甲基 4 苯基 1,2 ,3,6 四氢吡啶 (MPTP)制备成偏侧帕金森病猴模型 ,术后 5～ 6周给于吡贝地尔 (泰舒达 )治疗。定期行脑多巴胺转运体99mTc TRODAT 1SPECT显像 ,测量两侧纹状体及小脑的放射性摄取计数 ,计算两侧纹状体的特异性放射性摄取比值 (r)和不对称指数 (AI)。【结果】正常猴两侧纹状体的 r接近 ,AI- 5 2 8～ 6 11;右侧颈总动脉注射MPTP后的模型猴右侧纹状体的 r降低及 AI增大比非模型猴更明显。治疗组和非治疗组双侧纹状体的r同向变化 ,右侧改变更明显 ;治疗组的AI大部分升高 ;非治疗组的AI均降低。【结论】脑多巴胺转运体99mTc TRODAT 1SPECT显像有助于帕金森病的早期诊断 。To investigate the application of dopamine transporter imaging by SPECT in the diagnosis of Parkinson disease and the anti Parkinson disease effect of Piribedil on dopamine transporter. Eight rhesus monkeys were used for this study They were all hemiparkinsonian models induced by unilateral infusion of MPTP into the right common carotid artery Five or six weeks after final operation, they were divided into two groups, with and without administration of Piribedil(Trastal), named Piribedil group and non Piribedil group The dopamine transporter imaging by SPECT with 99m Tc TRODAT 1 were performed in regular intervals The radioactivity uptake was measured in bilateral striatum and cerebellum The ratio of specific radioactivity uptake [(ST CB)/CB] and Asymmetry Index (AI) were figured The specific radioactivity uptake ratios of two striatum were nearly the same in normal monkeys And AI ranged from -5 82 to 6 11 After one or more times infusion of MPTP, the ratio of the right side reduced and AI rose more obviously in hemiparkinsonian monkeys than in non hemiparkinsonian monkeys The bilateral ratios changed toward the same trend in the two groups It was apparent in the right side AI elevated in most monkeys of the Piribedil group, and decreased in all monkeys of the non Piribedil group. [Conclusion]The dopamine transporter imaging by SPECT with 99m Tc TRODAT 1 is helpful for the diagnosis of Parkinson disease in early stage Piribedil maybe interfere with the number of dopaminergic neurons

关 键 词：多巴胺转运体 帕金森病/诊断 帕金森病/治疗 TRODAT-1 体层摄影术 发射型计算机 单光子 吡贝地尔 猕猴属 

分 类 号：R742.5[医药卫生—神经病学与精神病学]