中山市EB病毒筛查阴性人群12年追踪随访  

12 Year Follow-up Study on Population with Negative Antibody of Epstein-Barr Virus in Zhongshan, Guangdong

作　　者：魏矿荣[1] 李济忠[2] 余炳辉[1] 郑受昂[1] 梁锦胜[1] 郭媛卿[1] 梁智恒[1] 柳青[3] 

机构地区：[1]中山市人民医院肿瘤研究所,广东中山528403 [2]中山大学研究生处,广东广州510275 [3]中山大学卫生统计教研室,广东广州510089

出　　处：《中山医科大学学报》2002年第3期232-234,共3页Academic Journal of Sun Yat-sen University of Medical Sciences

基　　金：国家重点科技攻关 (973 )基金资助项目 (96 90 6 0 1 0 3 )

摘　　要：【目的】探讨EB病毒在人体内的变化规律及其与鼻咽癌发病的关系 ,及其对鼻咽癌筛查策略的影响。【方法】通过前瞻性方法对中山市 1986 - 1987年鼻咽癌首次筛查EB病毒抗体阴性人群 (385 5 0人 )随访 12年的资料以及首次筛查阳性人群 (2 92 1人 )随访 7年的资料进行比较 ,观察上述人群EB病毒VCA/IGA的变化规律及其与鼻咽癌发病的关系。【结果】EB病毒抗体VCA/IGA阴性队列每年都有一定的转阳率 (2 2 8% ) ,其头 3年鼻咽癌发病风险仅为一般人群的 11%左右 ,以后逐渐增加 ,但仍低于一般人群 ;与阴性队列比较 ,阳性队列鼻咽癌发病风险高 ,相对危险度达 2 3 2 2倍 (P <0 0 5 )。【结论】VCA/IGA阴性人群有一定比例可转为阳性 ;VCA/IGA阴性队列在较长的时间内保持鼻咽癌发病较一般人群及阳性人群低 ;EB病毒可能是鼻咽癌发病因素 ,EB病毒检测可预测鼻咽癌发生风险 。Objectives] To observe the variation of antibody of Epsetin Barr virus(EBV)and its relationship with nasopharyngeal carcinoma(NPC)occurrence, and to explore the impact of this relationship on the NPC screening strategy. By 12 year follow up of population with negative antibody of EBV and 7 year follow up of population with positive antibody of EBV after first screening during 1986 1987, the NPC incidences were recorded and analyzed. The antibody of EBV among 22 8% of “negative population” changed to positive The risk of NPC kept in a lower level in “negative population” comparing with general population, Standardized incidence ratio (SIR) was only 11%t in the first 3 years and less than 30% in the remaining period The risk of NPC in the first 4 years was significantly lower than the remaining period The comparison of NPC incidence rates of “positive population” to that of “negative population” showed that the relative risk of NPC was 23 22 no matter how EBV antibody level changed during the follow up period [Conclusions] The antibody level of EBV in population was a dynamic process No matter how EBV antibody level changed, “negative population” kept a lower risk of NPC comparing to general population or “positive population”. The results suggested an etiological role of EBV to NPC and the first 3 years after screening was a high NPC risk period for “positive population” and relative safe period for “negative population”.

关 键 词：爱泼斯坦巴尔病毒抗体 鼻咽肿物 前瞻性研究 

分 类 号：R739.63[医药卫生—肿瘤]