岩舒注射液与放疗并用对肺癌患者免疫功能的影响  

Effect of immune function of lung cancer patients treated by combined Yanshu injection and radiotherapy.

作　　者：郭占文[1] 拱玉华[1] 孙英慧[1] 李玉[1] 田起和[1] 闫英[1] 

机构地区：[1]沈阳军区总医院,辽宁110016

出　　处：《中国综合临床》2002年第5期451-452,共2页Clinical Medicine of China

摘　　要：目的探讨岩舒注射液对放疗的肺癌患者免疫功能影响及抗肿瘤作用。方法对 78例接受放疗的非小细胞肺癌患者随机分成 2组 ,单放组和药放组 (放疗 +用药 )。采用单克隆抗体和流式细胞仪技术检测外周血液中 T细胞亚群、B细胞、NK细胞百分数。结果单放组放疗后 CD+ 3细胞、B细胞百分数降低 (P<0 .0 5 ) ,CD+ 4/ CD+ 8比值下降 (P<0 .0 5 ) ;药放组 CD+ 3、CD+ 4细胞升高 (P<0 .5 )。放疗后药放组比单放组 CD+ 3细胞数明显增高 (P<0 .0 1) ,CD+ 4/ CD+ 8比值升高 (P<0 .0 1)。近期总有效率药放组 (76.9% )显著高于单放组(5 3 .9% ) (P<0 .0 1)。结论岩舒注射液对放疗引起的免疫功能抑制有明显的保护作用和协同抗肿瘤作用。Objective To evaluate the effect of Yanshu injection with radiotherapy on immune function and anti neoplastic role of lung cancer patients.Methods 78 cases of non small cell lung cancer were randomly divided into two groups: external radiotherapy groups (ERG) and Yanshu injection+external radiotherapy groups (YERG).T lymphocyte subsets,B lymphocyte and NK cell percentage in peripheral blood lymphocyte were measured by monoclonal antibody and flow cytometry instrument.Results After radiotherapy,CD + 3 cell and B lymphocyte percentage were lower (P<0.05) and CD + 4/CD + 8 was lower in ERG (P<0.05),while CD + 3 and CD + 4 were increased in YERG (P<0.05) .CD + 3 was increased (P<0.01) and CD + 4/CD + 8 was high in YERG compared with ERG.Recent overall effective rate was higher in YERG group (76.9%) than that of ERG group (53.9%)(P<0.01).Conclusion Yanshu injection has a protective role in radiotherapy induced immune function repression and acts together in anti cancer action.

关 键 词：非小细胞肺癌 岩舒注射液 放射治疗 

分 类 号：R734.2[医药卫生—肿瘤]