端粒酶基因hTR在乳腺癌中的表达  

Expression of telomerase gene hTR in breast carcinoma

作　　者：李贵新[1] 徐功立[2] 张永庆[3] 王会东[3] 赵常在[3] 

机构地区：[1]山东大学临床医学院 [2]山东省立医院,山东济南250021 [3]潍坊市人民医院

出　　处：《山东医药》2002年第9期10-12,共3页Shandong Medical Journal

基　　金：山东省科学技术攻关计划基金资助项目 (98115 45 0 3 B)

摘　　要：用原位杂交的方法检测端粒酶基因 h TR在 4 6例乳腺癌及其癌旁组织、5 3例乳腺良性病变中的表达和分布情况。结果显示 ,4 6例乳腺癌中 h TR表达阳性率为 91.3% ;癌旁组织中为 0 ;5 3例乳腺良性病变中为3.9%。乳腺癌组织中 h TR的表达与癌旁组织、良性病变比较差异有显著性 (P均 <0 .0 1)。乳腺癌组织中 h TR的表达与肿瘤分期相关 (P<0 .0 5 ) ,与病理类型、淋巴结转移、肿瘤大小无相关性 (P均 >0 .0 5 )。认为端粒酶基因hWith in situ hybridization,the expression and distribution of telomerase gene hTR was observed in 46 cases of breast carcinoma tissues,46 cases of tumor adjacent tissues,53 cases of benign lesions.Results showed that the hTR was detected in 91.3%(42/46) of breast carcinoma.While in the adjacent tissues,the hTR positive rate was 0(0/46).The positive rate of hTR was 3.9%(2/53) in benign lesions.The positive detection of hTR expression in cancer group significantly different from those in the adjacent tissues and benign lesions group(P both<0.01).The expression of hTR correlated well with tumor stage(P<0.05),but not with histopathologic type,tumor size and lymph node metastasis(P all >0.05).It is suggested that the detection of telomerase hTR gene expression be useful in diagnosis in breast carcinoma.

关 键 词：端粒酶 乳腺癌 基因表达 HTR基因 原位杂交法 诊断 

分 类 号：R737.9[医药卫生—肿瘤]