金属硫蛋白基因在上皮性卵巢肿瘤中的表达及临床意义  

Expression of metallothionein gene in epithelial ovarian tumor

作　　者：严瑞兰[1] 辛晓燕[1] 金明[2] 王健[1] 

机构地区：[1]第四军医大学西京医院妇产科,陕西西安710032 [2]第四军医大学生物化学与分子生物学教研室,陕西西安710032

出　　处：《细胞与分子免疫学杂志》2002年第1期41-42,共2页Chinese Journal of Cellular and Molecular Immunology

摘　　要：目的 研究金属硫蛋白（ＭＴ）基因在上皮性卵巢肿瘤中的表达及临床意义。方法 采用ＳＡＢＣ免疫组化法，对７２例上皮性卵巢肿瘤中金属硫蛋白的表达进行检测。结果 恶性肿瘤、交界性肿瘤和良性肿瘤 ＭＴ的表达分别为 ６４． ４％、３０．０％和 １１．８％，恶性肿瘤、交界性肿瘤 ＭＴ的表达明显高于良性肿瘤（分别为Ｐ＜０．０１和Ｐ＜０．０５）。随肿瘤组织病理分级及临床分期的增高，ＭＴ的表达也增加（Ｐ＜０．０５）。ＭＴ高表达者的生存期明显缩短。结论ＭＴ参与了上皮性卵巢恶性肿瘤的发生与发展，并有可能成为一个判定预后的有效指标。Aim To examine the expression of metallothionein gene in epitheliol ovarian tumor and to explore its relationship with tumorigenesis. Methods MT expression in 72 ovarian tumor tis- sues was detected by SABC immunohistochemical staining. Results The positive rates of MT expression in malignant, borderline and benign tumors were 64.4%, 30.0% and 11. 8%, respectively. The MT expression in malignant and bordline tumor were obviously higher than that in benign tumors ( P <0. 01). MT expression in- creased with advancement clinical stage and pathological grading of tumor tissue. Lymph node metastasis correlated with MT expression (P <0. 05). The survival period of the patients with high MT ex- pression was shorter. than that of the patients with cow MT express- lon. Conclusion MT expression may play an important role in genesis and progression of malignant epithelial ovarian tumor. Thus MT is promising as an index of determining patient's prognosis.

关 键 词：金属硫蛋白 上皮性卵巢肿瘤 免疫组化染色 

分 类 号：R737.31[医药卫生—肿瘤]