江苏汉族人乙醛脱氢酶2基因型分布及其与饮酒习惯的关系  

ALDEHYDE DEHYDROGENASE-2 GENOTYPES AND DRINKING BEHAVIOR OF CHINESE IN JIANGSU PROVINCE

作　　者：吴建中[1] 丁建华[1] 高长明[1] 李苏平[1] 臧宇[1] 周建农[1] 苏平[1] 刘燕婷[1] 周学富[2] 王如鸿 丁保国[2] 

机构地区：[1]江苏省肿瘤防治研究所流行病学研究室,江苏南京210009 [2]江苏省泰兴市卫生防疫站慢性病防治科,江苏泰兴225500

出　　处：《癌变．畸变．突变》2002年第2期90-93,共4页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：江苏省社会发展基金重点项目资金资助 (BS990 2 6 1)

摘　　要：目的 :研究乙醛脱氢酶 2 (ALDH2 )基因多态性在江苏汉族人中的分布频率及其与饮酒习惯的关系。方法 :在江苏泰兴市选择 2 73例正常人进行流行病学调查研究 ,并应用聚合酶链反应 限制性片段长度的多态性 (PCR RFLP)方法检测研究对象的ALDH2基因型。结果 :ALDH2变异型等位基因在中国人中的分布频率为 47.2 5 %。ALDH2变异型等位基因携带者与ALDH2正常等位基因携带者之间饮酒频度和每次饮酒量间差异均无显著性。结论 :中国人ALDH2酶的活性普遍缺乏。人们的饮酒习惯与ALDH2基因型分布无明显的相关关系。Purpose: To analyze the genotype frequency of aldehyde dehydrogenase-2 (ALDH2), and evaluate the relationship between ALDH2 polymorphism and drinking behavior in Chinese. Methods: Epidemiological data were collected from 273 healthy persons in Taixing city of Jiangsu province in China, and ALDH2 genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The frequency of ALDH2 mutant allele was 47.25 % in Chinese. No difference was found between ALDH-2+1 and ALDH-2+{1*2}/ALDH-2+2 in drinking frequency and alcohol consumption per occasion. Conclusion: The ALDH-2+2 allele was relatively common in Chinese. Drinking behavior was not influenced by the individual genotypes of ALDH2.

关 键 词：乙醛脱氢酶2 酒精 乙醛 

分 类 号：R181.33[医药卫生—流行病学]