碳酸锂对抗放化疗肿瘤患者遗传及氧化损伤作用的研究  

INHIBITORY EFFECT OF LITHIUM CARBONATE ON GENETIC AND OXIDATIVE DAMAGE IN CANCER PATIENTS WITH RADIOTHERAPY AND CHEMOTHERAPY

作　　者：罗鹏[1] 张爱华[1] 李军[1] 岑笃才[2] 任渝江[2] 张碧霞[2] 汪希兰[1] 黄晓欣[2] 

机构地区：[1]贵阳医学院预防医学系卫生毒理教研室,贵州贵阳550004 [2]解放军第44医院肿瘤科,贵州贵阳550009

出　　处：《癌变．畸变．突变》2002年第2期98-101,共4页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：贵州省自然科学基金 (G95 6 )

摘　　要：目的 :探讨碳酸锂 (Li2 CO3 )对放化疗肿瘤患者有无抗遗传及抗氧化损伤作用。方法 :给予临床放化疗肿瘤患者Li2 CO3联合用药治疗 ,采用单细胞凝胶电泳试验、外周血淋巴细胞微核试验及生化试验方法测定DNA损伤、微核率 (MNF)、超氧化物歧化酶 (SOD)和谷胱苷肽过氧化物酶 (GSH Px)活力、疏基 ( SH)和丙二醛 (MDA)含量。结果 :随Li2 CO3 疗程及剂量的增加 ,联合用药组与单纯放化疗组相比DNA断裂分级、慧星尾长、MNF显著降低 (P <0 .0 5 ) ;SOD、GSH Px活力、 SH含量、WBC总数显著增高 (P <0 .0 1)。结论 :Li2 CO3 可降低肿瘤患者遗传损伤程度 ,提高其抗氧化酶活性 ,降低抗癌药物的骨髓抑制作用。Purpose: To observe the inhibitory effect of lithium carbonate (Li-2CO-3) on genetic and oxidative damage in cancer patients. Methods: The single cell gel electrophoresis assay (SCGE), micronucleus test were used to measure DNA and chromosomal damage. At the same time, SOD, GSH-Px, and-SH and MDA were detected by biochemical tests. Results: The genetic damage of peripheral blood cells in cancer patients was relieved gradually with Li-2CO-3 treatment, and the activity and content of the anti-oxidative material and WBC number increased significantly. Conclusion: Li-2CO-3 can inhibit genetic damage, increase the ability of anti-oxidation and relieve the myellogenic inhibition.

关 键 词：碳酸锂 肿瘤患者 淋巴细胞 遗传损伤 氧化损伤 

分 类 号：R73－36[医药卫生—肿瘤]