激光多普勒血流计测量家兔面神经微循环  

Measurement of facial nerve blood flow in rabbits using laser Doppler flowmetry

作　　者：李健东[1] 李学佩[1] 

机构地区：[1]北京大学第三医院耳鼻咽喉科,100083

出　　处：《中华耳鼻咽喉科杂志》2002年第3期184-187,共4页Chinese Journal of Otorhinolaryngology

基　　金：天津市科委 2 1世纪 青年基金资助项目 (983 70 3 11)

摘　　要：目的　研究面神经微循环障碍与神经嵌压及面瘫发病的关系。方法　用激光多普勒血流计 (laserDopplerflowmeter,LDF)测量 32只新西兰大白兔水平段面神经及其周围结构的血流。结果在水平段面神经管同一点重复测量 ,发现LDF是一种客观、稳定的测量方法 ,水平段面神经血流存在近侧高远侧低的规律 ,水平段面神经最低LDF值 (5 7 96± 2 4 5 9) ,高于上鼓室内壁 (2 1 17± 6 2 1)、水平半规管 (2 1 16± 6 39)、鼓膜张肌腱 (10 4 0± 5 97)等周围结构 (P <0 0 5 ) ,压迫面神经会造成神经微循环障碍 ,提示LDF可能在面瘫嵌压机理的研究中发挥作用 ,水平段面神经管上测得的LDF值可能成为一种帮助医师在复杂术野中准确辨认出面神经的得力工具 ,避免医源性面瘫的发生。Objective To study the microcirculation disorder of the facial nerve entrapment in rabbits Methods Laser Doppler Flowmetry (LDF) was used in the blood flow measurement of the horizontal segment of the facial nerve and other adjacent structures in 32 New Zealand White rabbits The repeated test was used to evaluate the stability of LDF Results An animal model was established to study the microcirculation of the facial nerve in rabbits The record of repeat test showed that LDF is a stable method LDF of the horizontal segment of the facial nerve is higher in the proximal end but lower in distal LDF in the distal part of the horizontal facial nerve(57 96±24 59) is higher than the semicircle canal(21 16±6 39), the medial wall of the attic(21 17±6 21), the tendon of the tensor tympani muscle(10 40±5 97) and other adjacent structures ( P <0 05) LDF probe may become a detector for surgeon to find the facial nerve in the complicated operation fields and prevent the iatrogenic facial paralysis Because the press on the nerve can induce the decrease of the LDF, we estimate LDF may be very useful in the study of facial nerve entrapment Conclusions LDF is a new, stable, objective method for microcirculation study on facial nerve, and very useful in pathophysiological investigation of peripheral facial paralysis

关 键 词：面神经 微循环 激光多普勒流量测定 面神经麻痹 

分 类 号：R745.12[医药卫生—神经病学与精神病学]