肝癌高发区HBsAg阳性青少年血清透明质酸、型胶原检测结果分析  

Analysis of Serum Hyaluronidase and Collagen Ⅳ of Teenagers with Positive HBsAg in High Incidence Area of Liver Cancer

作　　者：倪正平[1] 施平凡[1] 陆建华[1] 张启南[1] 黄飞[1] 李文广[1] 

机构地区：[1]启东肝癌防治研究所,江苏启东226200

出　　处：《中国慢性病预防与控制》2002年第2期65-67,共3页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的肝癌高发区 HBs Ag阳性及阴性青少年血清透明质酸 (HA)、 型胶原 ( - C)水平比较分析。方法用放免法测定 1 4 4例 1 6岁和 1 9岁 HBs Ag阳性及阴性青少年血清 HA、 - C。结果 HA和 - C在 1 6岁阳性组及 1 6岁阴性组中的异常率和均值都无显著差异。但 1 9岁阳性组 HA的异常率 (68.2 % )和均值〔(1 0 5.0± 41 .3) ng/ ml〕明显高于 1 9岁阴性组〔2 7.3%和 (58± 2 1 .5) ng/ ml〕;1 9岁阳性组和阴性组的 - C异常率和均值无显著差异。结论 HA可作为初步反映年龄大于 1Objective To analyze and compare the levels of serum hyaluronidase(HA) and collagen Ⅳ(Ⅳ C) between teenagers with and without positive HBsAg in high incidence area of liver cancer.Method 144 cases of teenagers age 16 and 19 with or without positive HBsAg were collected.The levels of HA and Ⅳ C of them were determined by radioimmunological method.Results There was no significant difference between abnormal rates and means of HA and Ⅳ C in age 16 groups with or without positive HBsAg.The abnormal rate and mean of HA was significantly higher in age 19 group with positive HBsAg〔68 2%,(105 0±41 3)ng/ml,respectively〕than in age 19 group with negative HBsAg〔27 3%,(58±21 5)ng/ml,respectively〕,but no significant difference in those of Ⅳ C between two groups.Conclusion HA could be one of items determined during the follow up interview for liver fibrosis.\;

关 键 词：透明质酸 Ⅳ型胶原 肝纤维化 慢性肝炎 肝硬化 肝癌 

分 类 号：R730.43[医药卫生—肿瘤] R735.7[医药卫生—临床医学]