水杉总黄酮对血小板聚集、血液流变性的作用及机制探讨  

Inhibitory Effect of total flavones of Metasequsia glytostroboides on platelet aggregation and hemarheology in rats and mechanism research

作　　者：敖英[1] 刘惟莞[1] 严常开 屠治本[3] 糜留西[3] 王红英[1] 

机构地区：[1]武汉大学医学院药理学教研室,武汉430071 [2]武汉市武钢职工总医院药械中心,武汉430080 [3]中国科学院武汉植物研究所,武汉430072

出　　处：《中国药理学通报》2002年第2期214-217,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助课题 No 3 9970 0 85

摘　　要：目的　观察水杉总黄酮 (FMG)对大鼠血小板聚集活性、血小板 5 HT释放反应、血浆NO含量及血液流变性的影响。方法　比浊法测定大鼠血小板聚集活性、荧光光度法测定血小板 5 HT释放反应、分光光度法测定血浆NO含量、血液流变全自动分析仪检测血液流变性。结果　FMG抑制大鼠血小板聚集活性 ,抑制血小板 5 HT释放 ,升高血浆NO含量 ,降低急性血淤大鼠的全血比粘度、血浆比粘度、红细胞电泳时间、红细胞压积、红细胞计数、细胞方程K值 ,改善大鼠的血液流变性。结论　FMG有抗血小板聚集活性、改善血液流变性的作用。其抗血小板聚集的作用机制可能与抑制血小板释放反应、增加体内NO合成及Ca2 +AIM To observe the effects of total flavones of Metasequsia glytostroboides Hu et Cheng(FMG) on platelet aggregation,5 HT release,NO contents of plasma and hemarheology in rats. METHODS Platelet aggregation was quantified by turbidimetric method.5 HT release was assayed by fluores cence technique. NO content of plasma was assayed by spectrophotometry. RESULTS FMG inhibited the platelet aggregation and 5 HT release, increased the NO content of plasma, decreased the whole blood viscosity, plasma viscosity, eryrocyte electrophoresis time, K value of erythrocyte sedimentation equation and RBC, improved the hemarheology of rats. CONCLUSION FMG can inhibit the platelet aggregation and improve the hemarheology in rats. The inhibition on 5 HT release, increase of NO contents of plasma and the inhibitory effect on Ca 2+ may be its mechanisms.

关 键 词：水杉总黄酮 血小板聚集 5-HT释放反应 一氧化氮 血液流变性 

分 类 号：R－332[医药卫生] R331