血管瘤组织中bFGF、PCNA的表达  

Expression of bFGF, PCNA in Hemangioma Tissue

作　　者：张端莲[1] 陕声国[2] 刘昱[1] 杨勇[1] 杨虹[3] 周乾毅[1] 

机构地区：[1]武汉大学医学院组织学与胚胎学教研室,武汉430071 [2]武汉大学人民医院整形科,武汉430060 [3]郧阳医学院组织学与胚胎学教研室,十堰442000

出　　处：《武汉大学学报（医学版）》2002年第2期110-113,共4页Medical Journal of Wuhan University

摘　　要：目的 :研究血管瘤及血管畸形的发病机制。方法 :采用组织化学方法及免疫组织化学方法 ,对临床收集的 4 8例手术切除新鲜血管瘤标本 ,进行光镜下组织结构观察、肥大细胞计数以及碱性成纤维细胞生长因子(bFGF)、增殖细胞核抗原 (PCNA)表达水平的检测。结果 :发现 4 8例标本中有血管瘤 36例 ,血管畸形 12例 ,其中增生期血管瘤 16例 ,消退期血管瘤 2 0例。肥大细胞数量及PCNA、bFGF表达水平在血管瘤增生期明显升高 ,与退化期有明显差异 (P >0 .0 5 )。结论 :血管瘤与血管畸形组织学结构有较大区别 ,同时肥大细胞计数及PCNA的检测有利于临床鉴别诊断血管瘤及血管畸形 ,并认为肥大细胞。Objective:To investigate the pathologic mechanisms of hemangioma and vascular malformation. Methods: 48 case fresh hemangioma operative specimens were studied by histochemical and immunohistochemistry method. Mast cell and basic fibroblast growth factor(bFGF) and proliferatily cell nuclear antigen(PCNA) were detected under hte light microscope. Results: 48 cases of 16 cases proliferating hemangioma,20 cases involuting hemangioma, and 12 cases vascula malformation was found. Expression of bFGF and PCNA were higher in proliferating hemangioma than that in involuting hemangioma (P<0.05). Expression of bFGF and PCNA were low in vascular malformation and normal skin. Conclusion: The histological structure of hemangioma is very different to vascular malformation, the counting of mast cell and the detection of PCNA can be useful to clinical differential diagnosis. Mast cell and bFGF may be the important factors which influence the pathogenesis of hemangioma.

关 键 词：血管瘤 增殖细胞核抗原 碱性成纤维细胞生长因子 

分 类 号：R732.2[医药卫生—肿瘤]