酸性同工铁蛋白和AFP联检对原发性肝癌诊断价值的研究  

Study on the Value of Combined Estimation of AcidicIsoferritin and Alpha-fetoprotein in the Diagnosis of Primary Liver Cancer

作　　者：张东方[1] 黄炜[1] 廖兆全[1] 陈征途[1] 黄济群[1] 

机构地区：[1]广州医学院肿瘤研究所,广州510182

出　　处：《广州医学院学报》2002年第1期32-34,共3页Academic Journal of Guangzhou Medical College

摘　　要：目的:探讨酸性同工铁蛋白(ＡＩＦ)与甲胎蛋白(ＡＦＰ)联合检测对原发性肝癌诊断的价值。方法:采用放射免疫测定法测定原发性肝癌 ７８例、转移性肝癌 ２２例、肝炎和肝硬化病人 ８４例,正常对照 ８０例血清 ＡＩＦ和 ＡＦＰ含量。结果:原发性肝癌、转移性肝癌、肝炎和肝硬化病人ＡＩＦ的阳性率分别为６０．３%、４０．０%和２３．８%,对原发性肝癌诊断的阳性率显著高于其它组(Ｐ＜０．０１)。ＡＩＦ和ＡＦＰ联合检测对原发性肝癌诊断的阳性率分别由６０．３%和６８．０%提高至 ９０．９%;诊断的特异性由 ７６．８%和 ８４．５%提高至 ９７．３%。结论:ＡＩＦ与 ＡＦＰ联合检测明显提高对原发性肝癌诊断的灵敏度和特异性。Objective: To investigate the value of combined estimation of acidic isoferritin ( AIF) and alpha-fetoprotein (AFP)in the diagnosis of primary liver cancer (PLC). Methods: The serum AIF and AFP levels were determined with radioimmunoassay( RIA) in 78 patients with PLC,22 patients with metastatic liver cancer(MLC) ,84 patients with hepatitis and cirrhosis,and compared with those of the normal control. Results: The positive rates of AIF in patients with PLC ,MLC,hepatitis and cirrhosis were 60.3% 、40.0% and 23.8% respectively. It was significantly higher in the PLC group than that of the other groups ( P < 0. 01 ). When AIF and AFP were determined in combination, the positive rate for diagnosis of PLC was increased from 60. 3% and 68. 0% respectively to 90. 9% , and the specificity from 76. 8% and 84. 5% respectively to 97. 3% . Conclusions: Combination assay of AIF and AFP remarkably increased the sensitivity and specificity for diagnosis of PLC.

关 键 词：肝肿瘤 诊断 酸性铁蛋白 甲胎蛋白 放射免疫测定法 

分 类 号：R735.7[医药卫生—肿瘤]