血清透明质酸、Ⅳ型胶原、层粘蛋白水平与慢性乙型肝炎肝纤维化的关系  

A Study on the Relationship Between Serum Levels of Hyaluronic Acid,Type Ⅳ Collagen, Laminin and Hepatic Fibrosis in Patients with Chronic Hepatitis B

作　　者：王晓春[1] 刘立鹏[1] 龙苏[1] 周毅刚[1] 徐绍锐[1] 罗向波 黄顺玲 

机构地区：[1]中南大学湘雅医学院生化教研室,湖南长沙410078 [2]长沙市六医院

出　　处：《中国医师杂志》2002年第4期369-371,共3页Journal of Chinese Physician

摘　　要：目的　研究血清肝纤维化指标透明质酸 (HA)、Ⅳ型胶原 (ⅣC)及层粘蛋白 (LN)与慢性乙型肝炎肝纤维化的关系。方法　对 2 5 2例慢性乙型肝炎患者用放射免疫法检测血清HA、ⅣC、LN水平及定量PCR检测血清HBV -DNA。结果　血清HA、ⅣC、LN水平与慢性肝炎发展呈正相关 ,且在慢性重度肝炎及肝硬化阶段处于最高水平 (P <0 0 1)。结论　血清HA、ⅣC、LN水平可不同程度反映肝纤维化程度 ,可作为肝纤维化血清检测指标。Objective To study the relationship between levels of hyaluronic acid(HA),type Ⅳ collagen(ⅣC),Laminin (LN) in sera and hepatic fibrosis in patients with chronic hepatitis B.Methods 252 sera from patients with chronic hepatitis B were collected to measure hyaluronate,type Ⅳ collagen,laminin by radioimmunoassay,and sera HBV-DNA were also tested by quantitative fluorescence PCR respectively.Results Serum concentrations of HA,ⅣC and LN were remarkably increased with the progression of the disease,and reached the highest levels in chronic severe hepatitis and liver cirrhosis(P<0 01).Conclusions Serum hyaluronate,type Ⅳ collagen and laminin could reflect the status of hepatic fibrosis.These serum markers were suitable for diagnosing hepatic fibrosas.

关 键 词：透明质酸 Ⅳ型胶原 层粘蛋白 慢性乙型肝炎 肝纤维化 

分 类 号：R575.2[医药卫生—消化系统]