MK-801对反复性脑缺血大脑皮层组织病理和超微结构的影响  

EFFECTS OF MK-801 ON CORTICAL HISTOPATHOLOGY AND ULTRASTRUCTURE IN REPEATED CEREBRAL ISCHEMIA IN RATS

作　　者：曹仁存[1] 郑彩梅[2] 欧阳尧[1] 

机构地区：[1]成都军区总医院神经内科,成都610083 [2]第三军医大学西南医院神经内科,重庆400038

出　　处：《西南国防医药》2002年第2期102-105,共4页Medical Journal of National Defending Forces in Southwest China

基　　金：全军"九五"医药卫生科研基金资助 NO :96D0 4 0

摘　　要：目的 :研究MK - 80 1对反复性脑缺血大脑皮层组织病理和超微结构的影响。方法 :应用光镜和电镜对比观察大鼠反复性与单次性脑缺血大脑皮层神经元的病理损害及应用MK - 80 1治疗后的影响。结果 :反复缺血组皮层损害明显重于单次缺血组 ;MK - 80 1能显著改善反复脑缺血皮层神经元缺血性损伤和超微结构损害。结论Objective: To investigate the effects of MK-801 on cortical histopathology and ultrastructure in repeated cerebral ischemia. Method: The light and electron microscopies were used to observe the neuronal damage in cerebral cortex following repeated cerebral ischemia in rats or single cerebral ischemia, and then to examine the effects of therapy with MK-801. Result: The neocortex damage in the repeated ischemic group was more severe than that in the single ischemic group. MK-801 ameliorated markedly the histopathological and ultrastructural damage of the cortical neuron following repeated cerebral ischemia. Conclusion: These findings indicate that excitotoxic mechanism play a major role in neuronal damage induced by repeated ischemic insults.

关 键 词：脑缺血 反复性缺血 大脑皮层 组织病理学 超微结构 MK-801 

分 类 号：R743.31[医药卫生—神经病学与精神病学]