高温碘油热栓塞治疗原发性肝癌患者  

Hyperthermal lipiodol embolization and thermocoagulation for the treatment of primary hepatocellular carcinoma

作　　者：李常青[1] 徐道振[1] 许东海[1] 李秀兰[1] 张伟[1] 刘悦德[1] 

机构地区：[1]北京地坛医院介入放射科,100011

出　　处：《中华肝脏病杂志》2002年第3期174-177,共4页Chinese Journal of Hepatology

摘　　要：目的 探讨高温碘油血管栓塞及热杀伤作用对原发性肝癌的疗效。方法 将131例原发性肝癌患者随机分为两组:热碘油栓塞组63例,化疗栓塞组68例。采用Seldiger方法,将导管超选择插入肿瘤供血动脉:(１)用110℃稀释热碘油脉冲式热栓塞;(２)用碘油化疗药物乳剂栓塞。结果 热栓塞组肿瘤缩小率和甲胎蛋白(AFP)复常率高于化疗栓塞组,而且术后临床不良反应轻,肝功能损害不明显,生存期较长。结论 高温稀释碘油流动性增加,对肿瘤滋养血管栓塞更为彻底,比热提高,对肿瘤细胞热杀伤作用增强。冶疗原发性肝癌疗效好,不良反应轻,适应证广。ve To explore the efficacy of hyperthermal lipiodol embolization and thermocoagulation for thetreatment of primary hepatocellular carcinoma. Methods One hundred and thirty-one cases were randomized into twogroups: the hyperthermal dilute lipiodol embolization group (63 cases) and the chemoembolization group (68 cases). WithSeldinger's method, We first placed the catheter to the targeting vessel superselectively and then put the hyperthermal dilutelipiodol (ll0℃) l0~30ml to the tumor vessels to IV degree for the former group; gave the lipiodol-epirubicin emulsion bythe same way to the latter group. Results The rate of tumor minification and AFP normalization in the hyperthermallipiodol embolization group was higher than that in the lipiodol-epirubicin embolization group. The side effects and the liverdamage were mild in the former group. The survival time of the patients in the former group was longer than that in the lattergroup. Conclusions Embolization of the tumor vessels with hyperthermal dilute lipiodol is more thorough due to its betterfluidity. The thermocoagulation of the hyperthermal dilute lipiodol becomes stronger for its higher specific heat. It is there-fore a good technique for the treatment of primary hepatocellular carcinoma.

关 键 词：原发性肝癌 碘油 栓塞治疗 疗效 

分 类 号：R735.7[医药卫生—肿瘤]