小剂量照射的抑癌增强作用及其对皮肤组织的影响  

Low Dose Irradiation Intensifying Effect on Cancer Inhibition and Its Influence on Skin Tissue

作　　者：郭月凤[1] 吴启庆[1] 陈学英[1] 田宇[1] 

机构地区：[1]中国辐射防护研究院,太原030006

出　　处：《辐射防护通讯》2002年第1期8-11,共4页Radiation Protection Bulletin

基　　金：山西省自然科学基金资助课题

摘　　要：本文采用 H2 2 肝癌小鼠肿瘤模型探讨小剂量照射的抑癌增强作用的优化剂量和作用机制。实验结果表明小剂量辐射具有抑癌增强作用 ,与化疗组相比联合治疗组种植瘤生长速度显著降低 (p <0 .0 1 )、腹水癌细胞死亡率显著增加 (p <0 .0 1 )。小剂量照射与环磷酰胺协同杀伤癌细胞可能是其机制之一。 6 0 Coγ线照射对荷瘤小鼠皮肤 Zn含量有一定程度的影响。本实验条件下既有抑癌增强作用又对皮肤 Zn含量影响较小的优化剂量为 1 4c Gy。The optimized dose and mechanism of low dose irradiation intensifying effect on cancer inhibition is investigated by using mice H 22 liver cancer model. The experimental result indicated that low dose irradiation has intensifying effect on cancer inhibition. The growth speed of planted tumors in the combined therapy groups significantly reduced (p<0.01) and the cancer cell death rate significantly increased (p<0.01) in comparison with in the chemical therapy. The synergism of low dose irradiation and cyclophosphamide killing cancer cells may probably be one of its mechanisms. Exposure to 60 Co γ rays at low doses may influence the Zn content of skin in mice bearing tumors to certain extent. Under this experiment condition, the optimized dose is 14 cGy at which irradiation had intensifying effect on cancer inhibition but less influence on the content of Zn in the skin.

关 键 词：抑癌增强作用 皮肤组织 小剂量照射 优化剂量 协同作用 肿瘤 放射治疗 

分 类 号：R73-36[医药卫生—肿瘤]