^(153)Sm-EDTMP和博宁治疗恶性肿瘤骨转移骨痛的疗效比较  

The Comparison of Radionuclide Therapy With ^(153)Sm-EDTMP and Chemotherapy With Pamidronate Disodium in the Patients With Painful Metastatic Bone Cancer

作　　者：王荣福[1] 朱绍莉[1] 朱玫[1] 

机构地区：[1]北京大学第一医院核医学科,北京100034

出　　处：《同位素》2002年第2期111-114,共4页Journal of Isotopes

摘　　要：为比较放射性药物^(153)Sm-EDTMP和化疗药物博宁对恶性肿瘤骨转移骨痛的疗效,将恶性肿瘤骨转移骨痛患者18例随机分为^(153)Sm组和博宁组各9例进行分组治疗;采用骨病状况评分标准,对患者治疗前后的骨痛状况进行评分。受试者治疗前骨痛评分均≥6分;止痛效果采用4级评定法。结果:^(153)Sm-EDTMP。组9例中2例好转,7例显效,无完全缓解,有效率为77.8％;博宁组9例中无效和加重4例,1例好转,显效3例,完全缓解1例,有效率44.4％;^(153)Sm-EDTMP对骨髓抑制作用为一过性,博宁无明显骨髓抑制作用;^(153)Sm-EDTMP与博宁治疗恶性肿瘤骨转移骨痛有效率相近(P=0.334 8),且疼痛减轻持续3周以上,但一过性血液毒性比博宁略为显著。To compare the therapeutic efficacy of radionuclide therapy with 153 Sm-EDTMP and chemotherapy with pamidronate disodium (PD) in the patients with painful metastatic bone cancer, eighteen patients histogically confirmed malignancy with multifocal bone metastases are randomized into the group 153Sm(9 patients treated with 153Sm-EDTMP) and the group PD (9 patients treated with PD) prior to study. The pain score in each patient prior to therapy is more than 6 according to scoring standardization bone pain situation and therapeutic response is classified as 4 grade (inefficient, better, effective and excellent relief). The results show that 7 of 9 patients ettective, 2 cases better, and the therapeutic effective rate is 77. 8% in the group 153Sm; 4 cases inefficient, 1 case better, 3 cases effective and 1 case excellent relief, and the therapeutic effective rate is 44. 4% in the group PD. No hematological toxicity is noted. The results revealed that the therapeutic effective rate of 153Sm-EDTMP is similar to that of pamidronate disodium (P = 0. 334 8), with pain relief maintaining more than 3 weeks, but its incidence of slightly side effect of blood toxicity is more significant than that of pamidronate disodium.

关 键 词：博宁 治疗 ^153SM-EDTMP 帕米磷酸二钠 恶性肿瘤 骨转移 骨痛 疗效 放射性药物 并发症 骨转移癌 

分 类 号：R738.1[医药卫生—肿瘤] R730.55[医药卫生—临床医学]