^(153)Sm-TTHMP的合成及在小鼠体内的分布  

PREPARATION AND BIODISTRIBUTION OF ^(153)Sm-TTHMP

作　　者：蒋树斌[1] 罗顺忠[1] 雷勇[2] 邓候富[2] 邴文增[1] 王文进[1] 魏洪源[1] 

机构地区：[1]中国工程物理研究院核物理与化学研究所,四川绵阳621900 [2]四川大学华西医院核医学科,四川成都610041

出　　处：《核化学与放射化学》2002年第2期105-108,共4页Journal of Nuclear and Radiochemistry

基　　金：国家自然科学基金资助项目 (2 97710 7)

摘　　要：制备了三乙烯四胺六甲撑膦酸 (TTHMP)的153 Sm标记物 ,研究了其标记条件、体外稳定性、化学计量组成、兔SPECT骨扫描及在小鼠体内分布。结果表明 ,在 pH =7 0～ 8 5时 ,高配体量有助于标记物的形成 ;标记物稳定性高 ,7d内放化纯度基本保持不变 ;本实验条件下制备的标记物的化学计量组成为n(153 Sm )∶n(TTHMP) =1∶1;兔骨骼显像和小鼠体内分布表明 。TTHMP (triethylenetetraaminehexamethylenephosphonic acid) is labeled with 153 Sm. The labeling condition, stability, molar ratio of 153 Sm to TTHMP, rabbit bone imaging and biodistribution of 153 Sm TTHMP in mice are investigated. The results show that weak basic media and high concentration ligands are favorable to form labeled compound, and 153 Sm TTHMP is stable at pH=7 in 7 d. The results also indicate that the mole ratio of 153 Sm TTHMP is n ( 153 Sm): n (TTHMP)=1∶1 and skeleton uptake of 153 Sm TTHMP reaches maximum value (13.96%/g) in 1 h after injection and is kept high (13.54%/g) in 48 h, while the non target tissue uptake is low. So 153 Sm TTHMP is a promising bone tumor therapeutic agent.

关 键 词：^153Sm-TTHMP 合成 三乙烯四胺六甲撑膦酸 骨肿瘤 生物分布 钐153 标记物 放射性核素 放射治疗 

分 类 号：R738.1[医药卫生—肿瘤] R730.55[医药卫生—临床医学]