大枣中性多糖对小鼠腹腔巨噬细胞胞浆游离Ca^(2+)浓度的影响  

Effect of neutral jujube date polysaccharide on [Ca^(2+) ]i in macrophages of mice

作　　者：张庆[1] 雷林生[2] 杨淑琴[2] 孙莉莎[2] 

机构地区：[1]第一军医大学南方医院药学部,广州510515 [2]第一军医大学药理学教研室,广州510515

出　　处：《中药药理与临床》2001年第3期14-17,共4页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的 :探讨大枣中性多糖 (JDP N)对小鼠腹腔巨噬细胞 (MΦ)胞浆游离Ca2 +浓度 ([Ca2 +]i)的影响。方法 :采用激光扫描共聚焦显微镜技术 (LSCM )测定 [Ca2 +]i。结果 :JDP N能引起MΦ内Ca2 +浓度 [Ca2 +]i明显升高 ,[Ca2 +]i的升高是由胞外Ca2 +内流和通过IICR(IP3 inducedcalciumrelease)和CICR(calcium inducedcalciumrelease)机制释放细胞内贮存Ca2 +引起。结论 :[Ca2 +]i升高是JDPObjective:[WT5”BZ] To study the effect of neutral Jujube date polysaccharide (JDP N) on [Ca 2+ ]i in macrophages. [WT5”HZ]Methods:[WT5”BZ] [Ca 2+ ]i was determined by Laser Scanning Confocal Microscope. [WT5”HZ]Result:[WT5”BZ] JDP N increased [Ca 2+ ]i in murine peritoneal macrophages through Ca 2+ induced calcium release (CICR), IP 3 induced calcium release (IICR) mechanism and Ca 2+ influx. [WT5”HZ]Conclusion:[WT5”BZ] Increasing of [Ca 2+ ]i may be the important signal transduction through which MΦ was activated by JDP N. [WT5”HZ]

关 键 词：大枣多糖 巨噬细胞 游离CA^2+浓度 激光扫描共聚焦显微镜 

分 类 号：R285.5[医药卫生—中药学]