人脑胶质瘤中Fas及FasL的表达  

Fas and FasL expression in human gliona.

作　　者：郑宇[1] 浦佩玉[1] 王春燕[1] 

机构地区：[1]天津医科大学总医院神经外科,天津300052

出　　处：《中国神经精神疾病杂志》2002年第3期179-181,I002,共4页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的　探讨Fas及FasL基因在人脑胶质瘤中的表达 ,与肿瘤的病理类型及恶性程度的关系。方法　应用Fas及FasL多抗和Ki 6 7单抗免疫组化染色检测 6例正常脑组织及 6 4例人脑胶质瘤。结果　Fas和FasL在胶质瘤中的总表达率分别为 83%和 75 % ,并随WHO分级升高而升高 ,与Ki 6 7LI呈正相关。Fas、FasL共同阳性率 (共表达率 )为 71% ,与肿瘤级别呈正相关。Objective To study the expression of Fas and FasL in human glionas and its relationship with histopathological type and degree of malignancy of glioma. Methods Fas/FasL expression, and Ki 67 labeling index (Ki 67LI) of 6 normal brain tissues, 64 glioma samples and 2 glioma cell lines were studied by immunohistochemical staining. Results Of the 64 gliomas, 53 (83%) expressed Fas, while 48 (75%) expressed FasL. The expression level increased with the increasing tumor grade, and positively correlated with Ki 67LI. The co expression rate was 71%, which was positively related with tumor grade. Conclusions Fas and FasL expression is related to histopathological type and degree of malignancy of gliomas.

关 键 词：脑胶质瘤 KI-67标记指数 FAS基因 FASL基因 基因表达 脑肿瘤 病理类型 免疫组织化学 

分 类 号：R730.264[医药卫生—肿瘤]