妥泰加用治疗成人部分性癫痫的疗效观察  

Therapeutic effect of topiramate as adjunctive therapy in adults with partial epilepsy

作　　者：陈文飞[1] 刘裕芬[1] 

机构地区：[1]海南省人民医院伽玛刀治疗中心,海口570311

出　　处：《海南医学》2002年第6期1-2,共2页Hainan Medical Journal

摘　　要：目的　观察妥泰 (TPM )加用治疗成人部分性癫痫的疗效、安全性及耐受性。方法　 30例在原用抗癫痫药 (AEDS)的基础上加用TPM治疗 2 0周 ,前 8周为加量期 ,后 1 2周为稳定期。治疗前 (基础期 )记录好发作频率、用药情况等作为对照。TPM自 2 5mg/d开始 ,每周增加 2 5mg ,达有效剂量 2 0 0mg/d后维持治疗量。治疗前及治疗结束各查基础AEDS血药浓度进行比较 ,观察其疗效及不良反应。结果　TPM加用治疗 2 0周后 ,与基础期发作频率比较 ,66 .67%患者发作频率降低≥ 50 % ;2 6 .67%患者发作频率降低≥ 75 % <1 0 0 % ;1 6 .67%患者完全不发作。不良反应轻至中度 ,但与合作AEDS的多少有关。TPM对基础AEDS血药浓度影响不大。Objective: To observe the therapeutic efficacy,safety and to lerability of Topiramate(TPM) as adjunctive therapy in adults with partial epilepsy.Methods:TPM as adjunctive therapy in 30 patients for 20 weeks,the first 8 weeks for titration phase,the last 12 weeks for stabilization phase.we recored the seizure frequency,dose situtation et al.before the treatmentand as the contrast.TPM stating dose was 25mg/d and then increased 25mg/d each week until the effective dose was 200mg/d of maintain therapy.The blood concentration of the AEDS blood compared before and after the treatment,and to observe the effectiveness and bad reaction were found.Results:After TPM adjunctive therapy for 20 weeks,as compared with the seizure frequencies in baseline phase,the seizure frequencies of 66.67% cases were reduced≥50%;the seizure frequencies of 26.67% cases≥75%≤100%;16.67% cases were totally controlled.Bad reaction were from mild to moderate,but it related to the dosage of AEDS.The effects of the blood concentration weren't great on TPM to the dose of AEDS.Conclusion:TPM is a safe,effective drug for treatiing adult patients with partial epilepsy.

关 键 词：妥泰 治疗 成人 部分性癫痫 疗效观察 加用治疗 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R971.6[医药卫生—临床医学]