cDNA表达点阵研究苦参碱诱导K562细胞凋亡基因表达的改变  

Apoptosis gene expression changes in K562 cells induced by matrine with cDNA expression array

作　　者：张永清[1] 黄高升[1] 冯骥良[1] 王哲[1] 杨国荣[1] 

机构地区：[1]第四军医大学基础部病理学教研室,陕西西安710033

出　　处：《第四军医大学学报》2002年第9期F002-F002,共1页Journal of the Fourth Military Medical University

基　　金：国家自然科学基金资助项目 (3 0 171186);第四军医大学创新工程资助 (CX0 10 0 4)

摘　　要：K562 cells can be induced to apoptosis by matrine, but the mechanism remains unknown. cDNA expression array was applied to study genes’ expression change of K562 cells induced by matrine. Expression of 16 genes was decreased, 11 of them belonged to genes of cyclins or CDKs, 4 of them were anti apoptosis genes, and expression of 19 genes was increased, 11 of them were proapoptotic genes.K562 cells can be induced to apoptosis by matrine, but the mechanism remains unknown. cDNA expression array was applied to study genes' expression change of K562 cells induced by matrine. Expression of 16 genes was decreased, 11 of them belonged to genes of cyclins or CDKs, 4 of them were anti apoptosis genes, and expression of 19 genes was increased, 11 of them were proapoptotic genes.

关 键 词：苦参碱 K562细胞 凋亡 基因变化 白血病 

分 类 号：R733.7[医药卫生—肿瘤]