乳腺癌组织中微血管密度检测的临床意义  

Clinical Significance of Microvessel Density in Breast Cancer

作　　者：邬一军[1] 周新惠[1] 黄钟英[1] 于吉人[1] 

机构地区：[1]浙江大学医学院附属一院,310003

出　　处：《实用癌症杂志》2002年第3期294-296,共3页The Practical Journal of Cancer

摘　　要：目的　探讨乳腺癌组织内微血管密度与乳腺癌临床病理特征及预后的关系。方法　采用免疫组化SABC法 ,检测 49例乳腺癌组织内微血管生成情况。结果　腋淋巴结阳性组微血管密度为 (116.0± 43 .2 )个 /mm2 ,阴性组为 (74.5± 3 2 .8)个 /mm2 ,两者有显著性差异。瘤体直径≤ 2 .0cm组微血管密度为 (68.5± 2 4.9)个 /mm2 ,>2 .0cm组为 (10 8.2± 42 .7)个 /mm2 ,两者有显著性差异。c erbB2阳性表达组微血管密度为 (110 .1± 43 .9)个 /mm2 ,阴性组为 (81.0± 3 8.9)个 /mm2 ,两者有显著性差异。复发组微血管密度为 (119.0± 3 9.6)个 /mm2 ,未复发组为 (64 .4± 2 4.1)个 /mm2 ,两者有显著性差异。结论　肿瘤组织内微血管的生成程度与乳腺癌的生长和转移密切相关 ,微血管密度可作为评估乳腺癌患者预后的指标之一。Objective To study the relationship between microvessel density(MVD) and clincal pathology and prognosis in breast cancer.Methods To determine the generation level of microvessel in 49 patients with breast cancer,the strepto avidin biotin peroxidase complex(SABC) was applied.Results MVD was significantly different between lymph node metastasis positive and negative group,tumor size ≤2.0 cm and >2.0 cm group,c erbB2 positive and negative group.There was also significant difference between recurrence and non recurrence group.Conclusion There are the close relationship between generation of microvessel and growth metastasis of breast cancer.The results indicate that examing MVD may be helpful in predicting prognosis of breast cancer.

关 键 词：乳腺癌 微血管密度 检测 临床意义 免疫组织化学 预后 

分 类 号：R737.9[医药卫生—肿瘤]