全脑缺血再灌注对大鼠空间分辨学习和记忆的影响  

The effect of global ischemia and reperfusion on learning and memory in rats

作　　者：魏秀娥[1] 耿德勤[1] 刘永海[1] 沈霞[1] 曾因明[2] 

机构地区：[1]徐州医学院附属医院神经内科,江苏徐州221002 [2]徐州医学院麻醉研究所,江苏徐州221002

出　　处：《徐州医学院学报》2002年第3期222-224,共3页Acta Academiae Medicinae Xuzhou

基　　金：江苏省麻醉学重点实验室开放课题资助项目 (K984 2 )

摘　　要：目的　探讨全脑缺血再灌注后不同时间对大鼠空间分辨学习和记忆能力的影响。方法　采用改良的Pulsinelli 4 -血管阻断 (4-vo)方法建立SD大鼠急性全脑缺血模型 ,缺血前后分别采用Y型迷宫试验对各组进行行为学定量测定。结果　全脑缺血再灌注后 3天、7天学习记忆能力明显下降。结论　急性全脑缺血再灌注使大鼠学习。Objective To investigate the effects of global ischemia and reperfusion on learning and memory in rats. Methods Acute global ischemia (15 min) rat model was produced by four-vessel occlusion (4-vo) as described by Pulsinelli-Brierley in Sprague-Daewley rats. The Y-type maze was used to test the behavior changes after global ischemia and reperfusion.Results The learning and memory ability of the rats was evidently reduced 3 d and 7 d after global ischemia and reperfusion.Conclusion Acute global ischemia and reperfusion impairs the learning and memory ability in rats.

关 键 词：全脑缺血 再灌注 大鼠 空间分辨 学习 记忆 

分 类 号：R743.31[医药卫生—神经病学与精神病学]