MTT法体外药敏试验指导下晚期肺癌的预见性化疗  

Predictive Chemotherapy of Advanced Lung Cancer Directed by MTT Assay in Vitro

作　　者：蒋芹[1] 李小民[1] 谢晓东[1] 张为民[1] 刘淑华[1] 苏彩女[1] 

机构地区：[1]连云港市第一人民医院,江苏连云港222002

出　　处：《河南肿瘤学杂志》2002年第3期173-175,共3页Henan Journal of Oncology

摘　　要：目的　研究MTT法体外药敏试验指导下晚期肺癌的预见性化疗。方法　 40例晚期肺癌 ,其中 2 0例作MTT法检测癌细胞对抗癌药的敏感性 ,根据药敏结果对患者进行化疗 ,无敏感药物者按经验方案化疗 ;另外 2 0例同期晚期肺癌患者按经验方案化疗 ,观察实验与临床结果的相关性。结果　 2 0例药敏试验者中阳性者 12例 ,阴性者 8例。实验提供敏感药物进行化疗者的有效率为75 % (9/12 ) ,实验提示耐药者按经验方案化疗 ,其有效率仅为 12 5 % (1/8)。卡方检验 χ2 =5 .2 0 8,P <0 0 2 5 ,差异显著。实验组中总有效率为 5 0 % (9+ 1/2 0 ) ;经验组 2 0例有效率为 3 0 % ,与药敏阳性组比较 ,χ2 =4 42 6,P <0 0 5 ,差异显著。Objective The predictive value of in vitro MTT assay for chemotherapy to lung cancer patients was studied.Methods For 40 patients, chemosensitivity testing of fresh tumour cells of 20 patients with lung cancer was conducted by the MTT assay. The MTT sensitive group chemotherapy according to the results of drugsensitivity in MTT assay. The MTT resistant group was given chemotherapy according to clinical experience. 20 patients in control group were given chemotherapy according to clinical experience. Results The MTT assay could be performed for the 20 patients. The response rate of sensitive group and resistant group was 75%(9/12) and 12.5%(1/8) respectively (χ 2=5.208, P <0 01). The difference was significant. The overall response rate in MTT assay group was 50%(10/20).The response rate in control group was 30% (χ 2=4 426, P <0 05) There was remarkable difference in the two groups. Conclusion The MTT assay can predict chemotherapy for lung cancer.

关 键 词：MTT法 体外药敏试验 晚期肺癌 预见性化疗 

分 类 号：R734.2[医药卫生—肿瘤]