BEPP方案治疗复发与难治性非霍奇金淋巴瘤近期疗效  

Short-Term Result of BEEP Regimen in the Treatment of Refractor and Relapsed non-Hodgkin's Lymphoma

作　　者：张宪真[1] 陈随芹[1] 

机构地区：[1]聊城市人民医院肿瘤科,山东聊城252000

出　　处：《河南肿瘤学杂志》2002年第3期180-181,共2页Henan Journal of Oncology

摘　　要：目的　观察平阳霉素 (PYM)、顺铂 (DDP)、足叶乙甙 (VP -16)联合化学治疗复发与难治性非霍奇金淋巴瘤 (non Hodgkin’slym phoma ,NHL)的近期疗效与毒性。方法　 2 7例中 ,中度恶性 11例 ,高度恶性 16例 ,中位年龄 47 3 4岁 ;难治性 11例 ,复发性NHL 16例。治疗方案 :DDP 40mg/m2 静滴d1～ 3 ,VP -1610 0mg/d静滴d1～ 5 ,PYM 10mg/d肌注d1,3 ,5 ,Pred 10 0mg/d口服d1～ 5 ,同时予以辅助止吐治疗及充分水化及利尿 ,2 1天为一个周期 ,连续应用 2个周期以上评价疗效。结果　 2 7例总缓解率 66 7% ,其中CR 7例 ,PR 11例 ;主要毒副反应为骨髓抑制与脱发 ,骨髓抑制多为Ⅰ～Ⅱ度 ,脱发 10 0 %。结论　BEPP方案治疗复发与难治性NHL疗效满意 ,不良反应轻 。Objective To observe the short-term effect of BEEP(PYM,DDP,VP-16,Pred) regimen on the treatment of refractory and relapsed non Hodgkin's Lymphoma.Method Median age of 27 patients was 47 years old and all had intermediate or high grade lymploma.11 patients suffered from refractory diseases,the others were relapsed NHL.All patients received DDP 40 mg/m 2,d1～3,VP-16 100 mg/d d1～5,PYM 10 mg/d,d1,3,5,Pred 100 mg/d d1～5.Cycles repeated for 21 days,all the patients received over two cycles of chemotherapy.Results In all the 27 patients, 66.7% of response rate was achieved with 7 cases of CR,11 cases of PR.Main toxicities were mild mylosuppression and baldness.Conclusion BEEP regimen can achieve a satisfactory sort term result in the treatment of refractory and relapsed NHL.It has low toxicity and can be well tolerated.

关 键 词：BEPP方案 复发 难治性非霍奇金淋巴瘤 近期疗效 化学疗法 

分 类 号：R733.1[医药卫生—肿瘤] R730.53[医药卫生—临床医学]