晚期大肠癌低剂量氟尿嘧啶及顺铂治疗近期疗效  

The Efficacy of Low Dose Fluorouracil and Cisplatin Continuous Infusion for the Treatment of Advanced Coloretal Carcinoma

作　　者：李斌[1] 秦光[2] 董震[1] 

机构地区：[1]山东省平阴县人民医院,山东平阴250400 [2]山东省泰安市中心医院,山东泰安271000

出　　处：《肿瘤学杂志》2002年第3期136-137,共2页Journal of Chinese Oncology

摘　　要：[目的]研究低剂量5氟尿嘧啶/顺铂(5 Fu/DDP)联合方案持续输注治疗晚期大肠癌的疗效及毒副反应。[方法]30例晚期大肠癌予以5 Fu250mg/m2·d,顺铂8mg/m2·d,通过输液泵控制滴速持续性输注18h,以21d为一个疗程 ,休息10d后重复 ,2个疗程评定疗效及毒副作用。[结果]30例晚期大肠癌中 ,CR4例(13.3%) ,PR12例(40.0%) ,CR +PR53.4 % ,毒副作用为骨髓抑制 ,恶心呕吐 ,粘膜炎及腹泻 ,但都为Ⅱ度以下毒副反应。[结论]DDP作为5 Fu的生物化学调节剂 ,与低剂量5 Fu联合应用 ,其近期疗效高 ,毒副作用低 。To study the efficacy and toxicity of the low dose 5-fluorouracil and cisplatin continuous infusion for treatment of advanced colorectal carcinoma.Thirty patients were enrolled in the trial.PF therapy consisted of 5-Fu(250mg/m2·d)and cisplatin(8mg/m2·d)continuous infusion 18hr per day for 21 days.After 10 days interval the next course was started.The efficacy and toxicity were evaluated after 2 courses.A complete response was observed in 4 cases and a partial response in 12 cases.The overall response rate was 53.4%.All Side effects included myelosuppression,nausea,vomiting and diarrhea were below Ⅱ degree.[Conclusions]PF therapy is a promising regimen for patients with advanced colorectal carcinoma.

关 键 词：化学疗法 晚期大肠癌 低剂量 氟尿嘧啶 顺铂 近期疗效 

分 类 号：R735.34[医药卫生—肿瘤] R730.53[医药卫生—临床医学]