孕烯醇酮唾液酸苷对小鼠记忆障碍的改善作用  

Effect of pregnenolone sialic glycoside on memory impairment in mice

作　　者：周斌[1] 张勤[1] 赵早瑞[2] 李文姬[3] 李绍顺[3] 姜远英[1] 殷明[1] 

机构地区：[1]第二军医大学药学院药理学教研室,上海200433 [2]浙江省医学科学院 [3]第二军医大学基础医学部药理学教研室

出　　处：《第二军医大学学报》2002年第5期562-563,共2页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金资助项目 (3 9770 849)

摘　　要：目的 :研究孕烯醇酮唾液酸苷对小鼠记忆障碍的改善作用。 方法 :以东莨菪碱制备小鼠记忆障碍模型 ,用水迷宫法测定小鼠的学习记忆功能。 结果 :小鼠腹腔注射东莨菪碱 4 mg/kg可造成明显的记忆障碍 ,给予孕烯醇酮唾液酸苷 (0 .1～ 5mg/kg,sc)对记忆有改善作用 ,在 1m g/kg剂量时能显著减少错误次数、缩短到达平台时间和游泳距离 (P<0 .0 5 )。 结论 :孕烯醇酮唾液酸苷有记忆增强作用。Objective: To investigate the antiamnesic effect of pregnenolone sialic glycoside on memory impairment in mice. Methods: Pharmacological model of amnesia in mice was produced by scopolamine. Learning and memory was evaluated using water maze performance of mice. Results: Significant memory deficit was induced by scopolamine (4 mg/kg, ip). Pregnenolone sulfate (0.1 5 mg/kg, sc ) failed to affect the scopolamine induced memory deficit. Pregnenolone sialic glycoside (0.1 5 mg/kg, sc) attenuated the deficit, decreased the time of finding platform, the errors of entering non exit and swimming distance at a dose of 1 mg/kg ( P <0.05). Conclusion: Pregnenolone sialic glycoside has memory enhancing effects.

关 键 词：孕烯醇酮唾液酸苷 孕烯醇酮硫酸酯 东莨菪 记忆障碍 老年性痴呆 动物实验 

分 类 号：R749.16[医药卫生—神经病学与精神病学]