选择性破坏胰腺A细胞的模型大鼠骨骼肌运动终板的电镜观察  

Ultrastructure Study of Motor End Plate of Skeleton Muscle of Model Rats with Selective Injured Islet A Cells

作　　者：张晓杰[1] 于秀文[1] 徐凤琳[1] 凌云[1] 张春庆[1] 王显艳[1] 

机构地区：[1]齐齐哈尔医学院病理教研室,黑龙江齐齐哈尔161042

出　　处：《解剖科学进展》2002年第2期111-112,共2页Progress of Anatomical Sciences

摘　　要：目的　探讨选择性破坏胰腺A细胞的模型大鼠胆碱能神经的变化。方法　选用硝酸钴和利血平选择性破坏大鼠胰腺A细胞后电镜观察骨骼肌运动终板胆碱能神经终末的变化。结果　硝酸钴组模型大鼠骨骼肌运动终板轴突终末含胆碱能神经递质乙酰胆碱的清亮小泡明显减少 (P <0 .0 1) ,利血平组明显增多 (P <0 .0 5 )。结论　这种内源性乙酰胆碱的变化可能与胰腺A细胞损伤有关 ,提示胆碱能神经除受其上级中枢调节外 。Objective To study the changes of cholinergic neurons in the model rats with islet A cell injured. Methods We selected Co(NH 3) 2·6H 2O and Phenethyldiguanide to destroy selective islet A cell,and observe ultrastructure of the motor end plate of skeleton muscle of cholinergic neuronal terminals. Results The number of AGV containing acetylcholine reduced obviously in cholinergic neuronal terminals in Co(NH 3) 2·6H 2O,s group(P< 0.01).The number of AGV increased obviously in Phenethyldiguanid group(P< 0.05). Conclusion This internal change of acetylcholine may be have relation to injury of islet A cell.This phenomenon indicates that cholinergic neuron has been adjusted by higher level centre and been adjusted by some endocrine cells.

关 键 词：骨骼肌 胰腺A细胞 胆碱能神经 运动终板 电镜 硝酸钴 利血平 神经损伤 药物副作用 

分 类 号：R74[医药卫生—神经病学与精神病学] R961[医药卫生—临床医学]