中枢神经系统疾病的基因治疗  

The gene therapy of central nervous system disorders

作　　者：张旺明[1] 牛东滨[1] 徐如祥[2] 王晓民[1] 

机构地区：[1]北京大学神经科学研究所,北京100083 [2]第一军医大学珠江医院神经外科,广州510282

出　　处：《基础医学与临床》2002年第3期206-211,218,共7页Basic and Clinical Medicine

基　　金：国家重点基础研究规划 (G19990 5 4 0 0 8)

摘　　要：基因治疗正在成为常规方法难以治愈的中枢神经系统疾病的新的治疗手段。本文概要介绍了中枢神经系统疾病基因治疗的方法和途径 ;中枢神经系统疾病基因治疗的病毒载体以及目前中枢神经系统疾病基因治疗研究的状况。Gene therapy is a potential and new methods of treating many neurological diseases that were considered refractory to current conventional treatments. By injection of viral vectors or transplantation of genetically engineered cells into specific sites of the brain, the development of technologies for delivery of foreign genes into brain opened the field to promising treatments for CNS disorders. But the development of gene therapy for neurological diseases represents a more complex problem than that for other systemic disorders. Incomplete characterization of target organs (brain and spinal cord) and additional challenges, such as post mitotic cells, heterogeneity of cell types and circuits, and limited access, all contribute to the difficulties. For this reason, this report provides an update outline of gene therapy in CNS and reviews current researches in this filed.

关 键 词：中枢神经系统疾病 基因治疗 病毒载体 

分 类 号：R741.05[医药卫生—神经病学与精神病学]