三种类型肺癌^(18)氟脱氧葡萄糖摄取量的初步研究  

Fluorine-18 fluorodeoxyglucose uptake in patients with primary lung cancer

作　　者：汪涛[1] 孙玉鹗[1] 周乃康[1] 姚树林[2] 王瑞民[2] 尹大一[2] 

机构地区：[1]解放军总医院胸外科,北京100853 [2]解放军总医院核医学科,北京100853

出　　处：《中华外科杂志》2002年第6期437-440,共4页Chinese Journal of Surgery

摘　　要：目的　探讨肺鳞癌、腺癌、细支气管肺泡癌对18氟脱氧葡萄糖 (fluorine 18fluorode oxyglucose,FDG)摄取的差异以及影响肺癌摄取FDG的常见因素。　方法　对 82例肺癌患者行全身或肺部正电子发射体层显像 (positronemissiontomography ,PET)检查 ,测定肿瘤组织FDG的标准摄取值(standarduptakevalue ,SUV)、最大与平均标准摄取值 (SUVmax、SUVmean)、正常肺组织的SUV(SUVlung)。　结果　 82例患者中 ,肿瘤组织对FDG的摄取能力均高于相应的正常肺组织 (P <0 0 1)。肺鳞癌、腺癌、细支气管肺泡癌的SUVmax分别为 8 4 2± 4 0 5 ,5 91± 3 91和 2 97± 1 10 ;SUVmean分别为 6 12± 2 90 ,4 35± 3 10和 2 2 5± 0 99,三者差异有显著性意义 (P <0 0 1)。SUV与肿瘤的大小呈正相关 (P <0 0 1)。血糖水平与正常肺组织的SUV对肿瘤的SUV有影响 (P <0 0 5 )。结论　 (1)肺癌组织对FDG的摄取能力高于正常肺组织 ,而且不同组织类型的肺癌之间SUV值差异有显著性意义。 (2 )肿瘤的大小与FDG摄取量存在着正相关性。 (3)Objective To assess the relationship between histological type and fluorine 18 fluorodeoxyglucose(FDG) uptake in patients with primary lung cancer and the factors affecting FDG uptake. Methods From October 1998 to April 2001, 82 patients with lung cancer were imaged with FDG PET (Positron emission tomography) before surgery or biopsy. Their maximum and mean standard uptake value(SUVmax and SUVmean) of tumor and SUV of normal lung(SUVlung) were measured. Results All tumors were detected by FDG PET.FDG uptake of tumor was higher than that of normal lung( P <0 01). FDG uptake was lower in adenocarcinoma(AC) than in squamous cell carcinoma(SQC), and that of bronchial aveolar carcinomas(BAC) was the lowest [SUVmax was 8 42±4 05,5 91±3 91 and 2 97±1 10,respectively; SUVmean was 6.12±2 90,4 35±3 10 and 2 25±0 99, respectively ( P <0 01)].Correlations were found between FDG uptake and tumor size ( P <0 01).Glucose level and SUV of normal lung could affect SUV of lung cancer( P <0 05). Conclusions SUV is higher in cancer tissue than in normal lung tissue. FDG uptake is different among SQC,AC and BAC.FDG uptake and tumor size appear to be correlated with each other.SQC,AC and BAC have their own features respectively.The effects of glucose and SUVlung should be considered in the diagnosis of lung cancer with PET.

关 键 词：肺癌 ^18氟脱氧葡萄糖 摄取量 放射性示踪 发射型计算机体层摄影术 鉴别诊断 

分 类 号：R734.2[医药卫生—肿瘤]