射频热疗加腹腔热灌注化疗治疗晚期腹盆腔恶性肿瘤21例的近期疗效分析  

SR-1000 radiofrequency chemohyperthermia for recurrent and metastatic peritoneo-pelvic malignant tumors

作　　者：罗京伟[1] 熊京红[1] 徐国镇[1] 余子豪[1] 李晔雄[1] 殷蔚伯[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤研究所肿瘤医院放射治疗科,北京100021

出　　处：《中华放射肿瘤学杂志》2002年第2期122-125,共4页Chinese Journal of Radiation Oncology

摘　　要：目的　探讨SR 10 0 0射频热疗机加腹腔热灌注化疗治疗复发或转移的晚期腹盆腔肿瘤患者的疗效及毒副反应。方法　 2 1例均为腹盆腔复发或转移的晚期肿瘤患者 ,卡氏评分 40～ 80分。9例合并有局部疼痛、14例合并有腹水。全部患者均经常规腹腔穿刺 ,腹腔内注入热生理盐水 1.0～2 .5L ,采用的化疗药物为顺铂、丝裂霉素、氟尿嘧啶等。然后通过SR 10 0 0提升腹腔温度到 40 .5～42 .5℃并维持 6 0～ 90min。热疗 2次 /周 ,热灌注化疗 1次 /周 ,每个疗程治疗 4～ 6次。结果　疼痛症状缓解 8例 ;腹水患者 14例中 10例达完全缓解 ,有效率为 71% ;脂肪硬结发生率为 14.3% ,腹内疼痛者发生率为 2 4.8%。结论　射频热疗加腹腔热灌注治疗复发或转移的晚期腹盆腔肿瘤是一种有效的治疗手段 ,值得在临床推广应用。Objective To evaluate the efficacy and tolerance of intraperitoneal chemohyperthermia(IPCH) with SR-1000 radiofrequency (RF) for recurrent or metastatic peritoneo-pelvic malignant tumors. Methods Twenty-one patients with recurrent or metastatic peritoneo-pelvic malignant tumors received chemohyperthermia,with 9 having local pain and 14 having ascites. The Karnofsky scores were 40-80. After abdominal cavity aspiration and infusion of hot NS and chemotherapeutic agents, the temperature of abdominal cavity was increased and maintained at 40.5-42.5?℃ for 60-90 minutes with SR-1000RF. Hyperthermia was given twice per week and chemotherapy once per week, with the whole treatment lasting for 2-4 weeks. The commonly used drugs were DDP?MMC?5-FU and so on. Results Local pain was relieved in 8 of 9 patients, complete disappearance of ascites in 10 of 14. The common side-effects were fat necrosis (14.3%) and abdominal pain (24.8%). Conclusions Intraperitoneal chemohyperthermia with SR-1000RF appears to be a promising new approach for patients with recurrent or metastatic peritoneo-pelvic malignant tumors, especially for those who did not response to systemic chemotherapy or whose tumor recurred after chemotherapy. As to bulky lesions, local supplementary radiotherapy should be given in order to obtain better local control.

关 键 词：放射频热疗 热灌注化疗 腹盆腔肿瘤 消化道肿瘤 妇科肿瘤 化学疗法 预后 

分 类 号：R730.5[医药卫生—肿瘤]