含盖诺化疗方案治疗复发性非霍奇金淋巴瘤的临床观察  

NVB and other 4 drugs combining chemotherapy for recurrent intermedium-high risk non-Hodgkin's Lymphoma

作　　者：金学军[1] 金杏泉[2] 王远东[1] 马磊[1] 刘东华[1] 柳子川[1] 

机构地区：[1]广州医学院临床肿瘤研究中心广州市肿瘤医院,广州510095 [2]复旦大学附属肿瘤医院化疗科,上海200032

出　　处：《临床肿瘤学杂志》2002年第3期224-225,共2页Chinese Clinical Oncology

摘　　要：目的 :观察盖诺 (NVB)、卡铂 (CBP)、异环磷酰胺 (IFO)、平阳霉素 (BLM A5 )、强的松 (PDN)组成的NCIBP方案治疗复发性非霍奇金淋巴瘤的近期疗效和毒副反应。方法 :采用NVB40mgivD1,8;CBP0 3ivd1;IFO1 0ivd1-3 Mesna0 4iv于IFO后 0、4、8小时各一次 ,d1-3 ;BLM A5 8mgimBiw× 2。结果 :全组 2 5例 ,CR16例 ,PR4例 ,总有效率 80 %。毒副反应主要是白细胞、血小板下降 ,发生率分别为 84%和 6 0 %,脱发发生率为 96 %。结论 :NCIBP方案治疗复发性非霍奇金淋巴瘤疗效较为满意。Objective:To observe the efficacy and toxicity of NCIBP combination regime in the treatment of recurrent non-Hodgkins lymphoma using Vinorelbine,Carboplatin,Ifosfamide,Pingyangmycin and Prednisone.Methods:40 mg/m 2 NVB was infused by push on d 1.8;0.3 g CBP iv by drop on d 1;1.0 g IFO iv by drop on day 1-3;0.4 g Mesna iv by drop 0,4,8 hrs after infusion of IFO on d 1-3;8 mg PYM im Biw ×2 with 5 mg DXM before;30 mg PDN orally d 1-14.Every four weeks as one cycle.Assessment was given after two or three cycles.Results:The total response rate in 25 patients was 16/25(80%) with 16 CR and 4 RR.Major toxicity were neutropenia and thrombocytopenia with occurrence rate 84% and 60%,Ⅲ to Ⅳ grade neutropenia are 20%(5/25).Conclusion:NCIBP regime has significant efficiency in the treatment of recurrent non-Hodgkin's lymphoma and worth further clinical study.

关 键 词：盖诺 复发性 非霍奇金淋巴瘤 临床观察 化学疗法 

分 类 号：R733.1[医药卫生—肿瘤] R730.53[医药卫生—临床医学]