应用cox回归模型分析脑白质疏松症对病死率的影响  

Effect of Leukoaraiosis on mortality in senile patients using cox regression model

作　　者：李庆华[1] 唐静怡[1] 欧阳文[1] 李征[1] 

机构地区：[1]解放军白求恩国际和平医院干部病房,石家庄050082

出　　处：《实用老年医学》2002年第3期139-140,共2页Practical Geriatrics

摘　　要：目的　 探讨脑白质疏松症 (LA)对老年人病死率的影响。　 方法　按 1∶1病例对照 ,对 6 9例老年LA患者与无LA对照组进行 5年的随访调查 ,统计 2组病死率 ,并采用cox回归模型进行多因素分析 ,以调查LA对老年人病死率的影响。　 结果 　LA组 5年病死率显著高于对照组 (分别为 6 0 9%及 33 3%,P <0 0 1) ;cox回归分析表明 :LA独立于高血压、既往脑卒中病史、心脏病及糖尿病史为老年人死亡的独立危险因素 (RR =1 90 ;95 %可信区间 1 11～ 3 2 2 ,P =0 0 19)。　 结论　LA为老年人死亡的独立危险因素。Objective To evaluate the mortality in patients with Leukoaraiosis(LA). Methods 69 elderly patients with LA and 69 age- and sex-matched non-LA subjects were investigated in a five-year follow-up study.the clinical data such as the age,histories of hypertension,previous stroke,diabetes mellitus,dyslipidemia,heart disease and smoking were analysed.The mortality,as well as the risk ratio(RR) of LA,was analyzed with cox regression model. Results The mortality of LA was significantly higher than that of non-LA group(60.9% vs 33.3% P<0.01).After controlling other major death predictors,the risk of death remained significantly higher(RR=1.90;95% CI 1.11～3.22,P=0.019). Conclusion Leukoaraiosis is a predictor of the death in elderly LA patients.

关 键 词：脑白质疏松 病死率 COX回归模型 

分 类 号：R742[医药卫生—神经病学与精神病学]