erbB4/HER4在非小细胞肺癌中的表达研究  

A study on the expression of erbB4/HER4 in non-small cell lung cancer

作　　者：徐永华[1] 江万里[1] 邓在春[2] 俞文英[3] 胡国平 郑如恒[5] 张敦华[5] 谭云山[5] 

机构地区：[1]中国科学院上海细胞生物研究所 [2]宁波大学附属医院呼吸科 [3]宁波大学附属医院病理科 [4]宁波大学附属医院胸外科 [5]复旦大学附属中山医院

出　　处：《中国肺癌杂志》2002年第3期177-179,共3页Chinese Journal of Lung Cancer

摘　　要：目的　检测第四人体表皮生长因子受体 (humanepidermal growth factorreceptor 4,HER4)在非小细胞肺癌 (non smallcelllungcancer ,NSCLC)组织中的表达 ,探讨HER4过度表达与NSCLC临床病理特征之间的关系。方法　采用免疫组化法检测 70例NSCLC(鳞癌 43例 ,腺癌 2 7例 )和远离癌灶的 2 0例正常组织中HER4的表达。结果　NSCLC中HER4过度表达率为 91.4% (64 /70 )。HER4过度表达与NSCLC淋巴结转移 (P =0 .0 0 7)、TNM分期 (P =0 .0 11)及术后生存率 (P =0 .0 2 5 8)有密切关系。结论　erbB4是晚期NSCLC生长的一个调控基因 ,干预HER4的过度表达可能是治疗晚期NSCLC的有效方法。Objective To detect the expression of human epidermal growth factor receptor 4 (HER4) and elucidate the relationship between its overexpression and the clinicopathological characteristics in non small cell lung cancer (NSCLC). Methods The expression of HER4 was detected in 70 cases of paraffin embedded NSCLC tissues by immunohistochemical assay. Results HER4 were overexpressed in 91.4% of NSCLC. The overexpression of HER4 was significantly related to lymph node metastasis (P=0.007), TNM stages (P=0.011) and postoperative survival rate (P= 0.025?8). Conclusion erbB4 is one of the genes to regulate the growth of advanced NSCLC. The artificial interference with HER4 overexpression may be a good way in the treatment of advanced NSCLC.

关 键 词：er4bB4基因 HER4蛋白 非小细胞肺癌 NSCLC 基因表达 

分 类 号：R734.2[医药卫生—肿瘤]