肝纤维化大鼠贮脂细胞的超微结构和免疫组织化学研究  

THE STUDY OF ULTRASTRUCTURE AND IMMUNOHISTOCHEMISTRY IN FAT-STORING CELL OF RAT WITH LIVER FIBROSIS

作　　者：薄爱华[1] 杨路亭 邢立强[1] 薛贵平[1] 许永利[1] 

机构地区：[1]张家口医学院超微病理学研究室,河北075029 [2]河北省三院消化科,河北050001

出　　处：《中国组织化学与细胞化学杂志》2001年第2期211-213,T003,共4页Chinese Journal of Histochemistry and Cytochemistry

基　　金：河北省教育厅自然科学基金资助项目!(NO. 98114)

摘　　要：探讨贮脂细胞在免疫性肝损伤时的形态学变化及意义。应用猪血清注射法造成大鼠肝纤维化 ,取肝脏做免疫组织化学染色和透射电镜观察。结果显示贮脂细胞数目增多 (P<0 .0 5 ) ,α-平滑肌肌动蛋白 (α- SMA)阳性 ,胞质内脂滴减少 ,粗面内质网和线粒体增多。结果表明贮脂细胞在肝纤维化过程中 ,细胞形态。In order to investigate morphology change of fat storing cell (FSC) after immune liver damage, the pig's serum were injected into abdomen of rat to induce liver fibrosis. The liver specimens were taken and prepared for immunohistochemical staining and electron microscopic observation. Result showed that the number of FSC in liver fibrosis were increased than normal group. The α SMA was positive in the FSC, endochontral reliculum and mitochondrion were increased and fat drap were lowered. The results suggested that change of morphology number and function of FSC were obvious in the process of liver fibrosis.\;

关 键 词：肝纤维化 大鼠 贮脂细胞 超微结构 免疫组织化学 肝脏 

分 类 号：R575.202[医药卫生—消化系统]