高压氧增加体外白血病细胞对化疗药物敏感性的观察  被引量:1

An observation of the effect of hyperbaric oxygen increasing the sensitivity of leukemia cells to chemotherapy in vitro

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作  者:谢晓平[1] 禹华玮[1] 尚振川[1] 周言新[1] 滕燕生[1] 

机构地区:[1]解放军第四○一医院,青岛266071

出  处:《中华航海医学与高气压医学杂志》2002年第2期86-88,共3页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘  要:目的 观察体外白血病细胞在化疗药和高压氧 (HBO)双重作用下对化疗敏感性的变化。方法 将 2 2例白血病患者的外周血每例分成 4份 ,各归入以下 4组 :1.用化疗药 +HBO组 ;2 .单用化疗药组 ;3.单用 HBO组 ;4 .对照组 (不加化疗药也不加 HBO) ;统计各组血样的白血病细胞死亡比率。结果  1组与 3组比较 P<0 .0 0 0 1;2组与 4组比较 P<0 .0 5 ;1组与 2组比较 P<0 .0 0 0 1;3组与 4组比较 P>0 .0 5。结论 肯定了化疗药对白血病细胞的杀伤作用 ,同时证明 HBO加化疗药组与单用化疗药组或单用 HBO组在体外白血病细胞杀死率差异非常显著 ,即 HBO能提高体外白血病细胞对化疗药的敏感性 ,另外只用Objective To observe the difference of leukemia cells killing rate between the groups of leukemia cells with chemotherapy plus hyperbaric oxygen(HBO) and the control groups. Methods The leukemia cells in vitro of 22 cases(divided into 4 groups) were detected. group 1: chemotherapy plus HBO; group 2: chemotherapy; group 3: HBO; group 4: blank control. The killing rate of leukemia cells of the 4 groups were calculated and statistically analyzed. Results Group 1 compared with Group 3, P <0 0001;group 2 compared with group 4, P <0 05; group 1 compared with group 2, P <0 0001; group 3 compared with group 4, P >0 05. Conclusions HBO can increase the sensitivity of leukemia cells to chemotherapy. There was no significance in the killing of leukemia cells in vitro with only HBO and no chemotherapy.

关 键 词:化疗 高压氧 白血病细胞-杀死率 

分 类 号:R730.5[医药卫生—肿瘤]

 

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