合成尼泊金甲酯的新方法  

New Method of Synthesis of Nipagin Ester

作　　者：高丽新[1] 张培权[1] 杨萍[1] 

机构地区：[1]鞍山钢铁学院应用化学系,114002

出　　处：《化学工程师》2002年第3期3-4,共2页Chemical Engineer

摘　　要：本文研究了以高压釜为反应容器 ,以Al2 (SO4) 3·1 8H2 O为催化剂 ,由既作反应物又作溶剂的甲醇及对羟甲酸为原料合成尼泊金甲酯。讨论了催化酯化的各种影响因素 ;实验表明 ,在醇酸摩尔比 3 5 :1 ,反应温度 1 3 0℃ ,反应时间 3h ,催化剂与酸摩尔比 0 0 6 5 :1的条件下 ,酯收率达 88 7% ,酯含量大于 99%This paper studied the synthesis of nipagin ester by mechyl alcohol that was both reaction mass and soluent and p -hydroxy benzoic acid in a high-pressure reactor,the catalyst was hydrated aluminium sulfate.A variety of influence factors of esterification and catalysis were also discussed.The experiments showed,when alcohol:acid(mol ratio)=35:1,catalyst:acid(mol ratio)=0.065:1,keeping the reaction at 130℃ for 3 hours,that the yield of ester was 88.7% and the purity of ester was over 99%.

关 键 词：尼泊金甲酯 水合硫酸铝 催化酯化 合成 防腐剂 

分 类 号：TQ225.24[化学工程—有机化工]