单向释药双层缓释贴膜治疗口腔溃疡的疗效观察  

Therapeutic effects of one-way sustained-release bistratal drug-film for oral ulcer

作　　者：刘国勤[1] 马晓蓬[1] 宋培智[1] 刘海英[1] 侯惠民[2] 贺芬[2] 

机构地区：[1]解放军第411医院海军口腔专科中心,上海200081 [2]上海医药工业研究院

出　　处：《第二军医大学学报》2002年第6期667-668,共2页Academic Journal of Second Military Medical University

摘　　要：目的 :考察醋酸地塞米松双层缓释贴膜对口腔溃疡的临床疗效。方法 :随机收集 1998年 6月至 2 0 0 1年 9月复发性口疮 344例 (含对照组 114例 )、扁平苔藓 193例 (含对照组 6 8例 )、放射性粘膜炎 130例 (含对照组 4 9例 ) ,共 6 6 7例 (含对照组 2 31例 )。采用随机单盲法以醋酸地塞米松双层贴膜 A (治疗组 )和安慰片 B(对照组 )进行临床验证。结果 :治疗组总有效率为 96 .1% ,与对照组比较有极显著性差异 (P<0 .0 1) ,无 1例出现不良反应。 结论 :该贴膜用于治疗口腔溃疡 ,临床疗效非常显著。Objective:To evaluate the therapeutic effect of sustained release bistratal drus film containing dexamethasoni acetate (DA) in treatment of oral ulcer. Methods:Totally 667(231 cases as control group) patients (June 1998 to September 2001) with recurrent aphthous ulcer, lichen planus, radio catarrh were studied randomly to evaluate the therapeatic effect in a single blind random way. Results:The effective rates of treated group and control group were 96.1% and 28.6%, respectively, and the difference between 2 groups was significant ( P <0.01). None of 667 cases had side effects. Conclusion:DA sustained release bistratal drug film is a new medicine for treating oral ulcer.

关 键 词：单向释药 双层缓释贴膜 口腔溃疡 疗效观察 

分 类 号：R781.5[医药卫生—口腔医学] R944.9[医药卫生—临床医学]