碱性成纤维细胞生长因子与阿尔茨海默病  

Basic fibroblast growth factor and Alzheimer's disease

作　　者：朱大明[1] 洪岸[1] 林剑[1] 

机构地区：[1]暨南大学生物工程研究所,广东广州510632

出　　处：《中国病理生理杂志》2002年第5期588-592,共5页Chinese Journal of Pathophysiology

基　　金：~~

摘　　要：Alzheimer’s disease(AD),which is one type of senile deimentia, has three remarkable pathologic characteristics-senile plaque,neurofibrillar tangles and neuronal death. As a neurotrophic factor, basic fibroblast growth factor(bFGF)is closely related to AD. This article reviewed the interaction between bFGF and AD-associated gene products(such as amyliod β protein,presenilin, apoloprotein E and microtubulin associated protein tau)and neuronal apoptosis. Some researchers suggested that bFGF may be put forward as potential therapeutic agent in AD and play a role in preventing or retarding the pathological process of this disease, alleviating or even eradicating the pathological insults of this disease.Alzheimer's disease(AD),which is one type of senile deimentia, has three remarkable pathologic characteristics-senile plaque,neurofibrillar tangles and neuronal death. As a neurotrophic factor, basic fibroblast growth factor(bFGF)is closely related to AD. This article reviewed the interaction between bFGF and AD-associated gene products(such as amyliod β protein,presenilin, apoloprotein E and microtubulin associated protein tau)and neuronal apoptosis. Some researchers suggested that bFGF may be put forward as potential therapeutic agent in AD and play a role in preventing or retarding the pathological process of this disease, alleviating or even eradicating the pathological insults of this disease.

关 键 词：碱性成纤维细胞生长因子 阿尔茨海默病 细胞凋亡 蛋白质类 BFGF 

分 类 号：R749.16[医药卫生—神经病学与精神病学]