尿中麻黄碱类药物的气相色谱检测法  

THE IDENTIFICATION OF EPHEDRINE AND ITS ANALOGUES IN URINE BY GAS CHROMATOGRAPHY

作　　者：李临[1] 崔建芳[1] 崔凯荣 周屹 王慕邹[1] 

机构地区：[1]中国医学科学院药物研究所,北京100050 [2]国家体委运动医学研究所,北京100061

出　　处：《药学学报》1991年第1期67-71,共5页Acta Pharmaceutica Sinica

摘　　要：麻黄碱及其类似物有兴奋作用,属体育比赛禁用药。这类化合物的化学结构相似,故有相似的鉴别特征。本文报道了以气相色谱对尿中麻黄碱(ephedrine)、甲基麻黄碱(methylephedrine)、乙基麻黄碱(ethylephedrine)、去甲麻黄碱(norephedrine)及去甲伪麻黄碱(cathine)进行检测,最后以气质联用法进行确证。本法操作简便,灵敏度高,结果可靠。A sensitive and reliable method of analysis for ephedrine and its analogues was established by using GC and GC-MS. The columns used for both GC and GC-MS were HP-5, and the carrier gas was helium. NPD was used as the detector for GC. The urine sample was extracted with ether and submitted to GC. If positive, it was then submitted to GC-MS to identify its structure. The detection limits for ephedrine and its analogues are lower than 200 ng/ml urine. The recoveries are above 80%.

关 键 词：麻黄碱 气相色谱 检测 尿 

分 类 号：R914.1[医药卫生—药物化学]