三七皂甙C1对四氧嘧啶糖尿病小鼠的降血糖作用  

HYPOGLYCEMIC EFFECT OF SANCHINOSIDE C1 IN ALLOXAN-DIABETIC MICE

作　　者：贡云华[1] 蒋家雄[1] 李泽[1] 朱立华[1] 张子昭[1] 

机构地区：[1]昆明医学院药理教研室细胞毒理室,昆明650031

出　　处：《药学学报》1991年第2期81-85,共5页Acta Pharmaceutica Sinica

摘　　要：三匕皂甙Cl(简称Cl)能降低四氧嘧啶糖尿病小鼠血糖,效应随连续给药而增强,并呈量—效关系趋势,与胰岛素的降糖效应无协同或拮抗作用。单剂量Cl对四氧嘧啶糖尿病小鼠的血浆胰岛素和肝脏cAMP浓度无明显影响;但能促进大鼠分离肝细胞摄取[~3H]葡萄糖,还能增加小鼠肝匀浆代谢葡萄糖和琥珀酸钠的耗氧量以及小鼠肝糖原的合成。Sanchinoside C1(ginsenoside Rg1), one of the major effective components of Panax notoginseng, was reported to be effective in lowering glucose-induced hyperglycemia and synergizing the action of insulin in normal animals. The present study was aimed at investigating its effects on diabetic animals and comparing them with that of insulin. The results showed that sanchinoside C1 was able to lower plasma glucose level in alloxan- diabetic mice. The action was strengthened with repeated administration and tended to be dose - dependent; its effect la s ted for more than four hours and no synergism or antagonism between sanchinoside C1 and insulin was observed. A single dose of sanchinoside C1 neither elevated plasma insulin level nor lowered hepatic cAMP level in alloxan-diabetic mice; while the uptake of [~3H] glucose by isolated rat hepatocytes, oxidation of glucose and sodium succinate in liver homogenate and synthesis of liver glycogen in normal mice were increased.

关 键 词：三七皂甙 血糖 糖原 降血糖作用 

分 类 号：R285.6[医药卫生—中药学]